Ethno-genetics of AIM1 gene relating to Human Skin Pigmentation among Six Indigenous Nationalities in Nepal

Authors

  • Nanda Bahadur Singh Unit of Human Biology and Genetics, Department of Biological Sciences, School of Science, University of Tokyo and Central Department of Zoology, T. U. Kathmandu

DOI:

https://doi.org/10.3126/jist.v20i2.13959

Keywords:

Human skin pigmentation, melanoma, polymorphism

Abstract

This paper attempts to find out allele frequencies of AIM1 gene among six ethnic groups in Nepal by detecting a total number of 456 blood and nail samples through an allele specific PCR amplification. The research findings revealed that the AIM1 codon L374F polymorphism distinctively showed conspicuous ethnic distribution of the two alleles; namely allele “F” was found mostly high (11.4%) in the Caucasoid Chidimar and rarely low (1.1%) in the Dravidian Munda whereas Mongoloid Chepang, Gurung, Raute and Thakali entirely lacked the “F” allele and showed the monomorphic type for the “L” allele. The codon L374F could be the best genetic marker for distinguishing Caucasian populations from Mongoloid ones and would explain the ethno-genomics of human skin coloration among many ethnic groups in the world.

Journal of Institute of Science and Technology, 2015, 20(2): 90-93

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Published

2015-11-26

How to Cite

Singh, N. B. (2015). Ethno-genetics of AIM1 gene relating to Human Skin Pigmentation among Six Indigenous Nationalities in Nepal. Journal of Institute of Science and Technology, 20(2), 90–93. https://doi.org/10.3126/jist.v20i2.13959

Issue

Vol. 20 No. 2 (2015)

Section

Research Articles

License

The views and interpretations in this journal are those of the author(s). They are not attributable to the Institute of Science and Technology, T.U. and do not imply the expression of any opinion concerning the legal status of any country, territory, city, area of its authorities, or concerning the delimitation of its frontiers of boundaries.

The copyright of the articles is held by the Institute of Science and Technology, T.U.