Formulation and in-vitro Evaluation of Oro-dispersible tablets of Indomethacin

Authors

  • Gopal Pokhrel Department of Pharmacy, Karnali College of Health Sciences, Kathmandu, Nepal
  • Ganga Kunwar Department of Pharmacy, Karnali College of Health Sciences, Kathmandu, Nepal
  • Jun Devi Rai Department of Pharmacy, Karnali College of Health Sciences, Kathmandu, Nepal
  • Sheela Thapa Department of Pharmacy, Karnali College of Health Sciences, Kathmandu, Nepal
  • Sudip Dhakal Department of Pharmacy, Karnali College of Health Sciences, Kathmandu, Nepal
  • Prashant Basnet Aadee Remedies Pvt. Ltd, Lalitpur, Nepal

DOI:

https://doi.org/10.3126/njhs.v2i1.47172

Keywords:

Direct compression, indomethacin, oro-dispersible, superdisintegrants

Abstract

Introduction: Oro-dispersible tablets are rapidly dissolved in saliva without the need for water and are beneficial for renal impaired, bedridden and psychiatric patients.

Objective: The study aimed to formulate oro-dispersible tablets of indomethacin with reduced adverse effects, better patient compliance, faster action, and convenience for patients.

Methods: Oro-dispersible tablets of indomethacin were prepared using three different super disintegrants; crospovidone, croscarmellose sodium and sodium starch glycolate with three different concentrations (2.5%, 5.2%, and 7.7%) by direct compression method. The prepared tablets were evaluated for pre and post-compression parameters including bulk density, tapped density, compressibility index, angle of repose, Hausner's ratio, hardness, friability, wetting time, in vitro disintegration time, and in vitro drug release.

Results: The percentage of drug released in 5 minutes of all formulations of Oro-dispersible tablets of Indomethacin was found to be 74.36% to 80.16% and the percentage of drug released in 10 minutes was 96.18% to 100%. All formulations showed disintegration time in the range of 19-78 seconds. The tablets prepared with 7.7% crospovidone (F6) shows faster disintegration (19 seconds) as compared to tablets prepared with sodium starch glycolate and croscarmellose sodium. The in-vitro dissolution studies showed that tablets of formulations batch containing 7.7% crospovidone releases 100% of the drug after 10 minutes which was fast released as compared to sodium starch glycolate and croscarmellose sodium.

Conclusions: Oro-dispersible tablets of indomethacin prepared with crospovidone showed better disintegration time and dissolution profile as compared to other superdisintegrants.

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Published

2022-08-03

How to Cite

Pokhrel, G., Kunwar, G., Rai, J. D., Thapa, S., Dhakal, S., & Basnet, P. (2022). Formulation and in-vitro Evaluation of Oro-dispersible tablets of Indomethacin. Nepal Journal of Health Sciences, 2(1), 90–97. https://doi.org/10.3126/njhs.v2i1.47172

Issue

Section

Research Articles