Study of Glycated Haemoglobin and Lipid Profile in Type-2 Diabetes Mellitus

Authors

  • Tapeshwar Yadav Department of Biochemistry, Madan Bhandari Academy of Health Sciences, Hetauda, Nepal
  • M. Vijaya Bhaskar Department of Biochemistry, Nizam’s Institute of Medical Science, Hyderabad(T.S), India
  • Jayendra Bajracharya Department of Biochemistry, MadanBhandari Academy of Health Sciences, Hetauda, Nepal
  • S. S. B. Sharma Department of Biochemistry, Bhaskar Medical College, Hyderabad (T.S), India
  • Nikky Maharjan Emergency Department, Alka Hospital, Jawalakhel, Lalitpur, Nepal
  • Sushma Bhadeshwar Department of Nursing, Gajendra Narayan Singh Sagarmatha Hospital, Rajbiraj, Saptari, Nepal

DOI:

https://doi.org/10.3126/njhs.v2i1.47157

Keywords:

Diabetes Mellitus, Glycated Haemoglobin, Lipid Profile

Abstract

Introduction: Diabetes Mellitus is characterized by chronic hyperglycemia with disturbances of carbohydrate, fat, and protein metabolism resulting from defects in insulin secretion, insulin action, or both.

Objective: To compare the biochemical parameters which included glycated hemoglobin, serum total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol of people with diabetes mellitus and matched nondiabetic controls.

Methods: The cross-sectional hospital-based study was conducted among 60 diabetics and 30 nondiabetic patients. Fasting blood samples of 5 ml were collected from both the study sample and control sample. Biochemical parameters like glycated hemoglobin, serum total cholesterol, serum triglyceride, serum high-density lipoprotein cholesterol, and serum low-density lipoprotein cholesterol were analyzed with the help of a semi-automated analyzer, Erba Chem5, and Colorimeter-Systronic. Means of glycated hemoglobin, total cholesterol, triglyceride, high-density lipoprotein, and low-density lipoprotein were estimated
among the cases and controls. The student`s t-test was used to compare the mean values.

Results: A statistically significant difference was observed in mean glycated hemoglobin, total cholesterol, triglyceride, high density lipoprotein and low-density lipoprotein among the cases and controls (p-value<0.05).

Conclusions: This study concluded that there was a significant difference in mean glycated hemoglobin, total cholesterol, triglyceride, high-density cholesterol, and low-density cholesterol among the cases and controls. It is suggestive that lipid profile must be considered among diabetic patients which could be beneficial to prevent the risk of cardiovascular complications.

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Published

2022-08-03

How to Cite

Yadav, T., Bhaskar, M. V., Bajracharya, J., Sharma, S. S. B., Maharjan, N., & Bhadeshwar, S. (2022). Study of Glycated Haemoglobin and Lipid Profile in Type-2 Diabetes Mellitus. Nepal Journal of Health Sciences, 2(1), 17–21. https://doi.org/10.3126/njhs.v2i1.47157

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Section

Research Articles