Study of Glycated Haemoglobin and Lipid Profile in Type-2 Diabetes Mellitus

Authors

  • Tapeshwar Yadav Department of Biochemistry, Madan Bhandari Academy of Health Sciences, Hetauda, Nepal
  • M. Vijaya Bhaskar Department of Biochemistry, Nizam’s Institute of Medical Science, Hyderabad(T.S), India
  • Jayendra Bajracharya Department of Biochemistry, MadanBhandari Academy of Health Sciences, Hetauda, Nepal
  • S. S. B. Sharma Department of Biochemistry, Bhaskar Medical College, Hyderabad (T.S), India
  • Nikky Maharjan Emergency Department, Alka Hospital, Jawalakhel, Lalitpur, Nepal
  • Sushma Bhadeshwar Department of Nursing, Gajendra Narayan Singh Sagarmatha Hospital, Rajbiraj, Saptari, Nepal

DOI:

https://doi.org/10.3126/njhs.v2i1.47157

Keywords:

Diabetes Mellitus, Glycated Haemoglobin, Lipid Profile

Abstract

Introduction: Diabetes Mellitus is characterized by chronic hyperglycemia with disturbances of carbohydrate, fat, and protein metabolism resulting from defects in insulin secretion, insulin action, or both.

Objective: To compare the biochemical parameters which included glycated hemoglobin, serum total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol of people with diabetes mellitus and matched nondiabetic controls.

Methods: The cross-sectional hospital-based study was conducted among 60 diabetics and 30 nondiabetic patients. Fasting blood samples of 5 ml were collected from both the study sample and control sample. Biochemical parameters like glycated hemoglobin, serum total cholesterol, serum triglyceride, serum high-density lipoprotein cholesterol, and serum low-density lipoprotein cholesterol were analyzed with the help of a semi-automated analyzer, Erba Chem5, and Colorimeter-Systronic. Means of glycated hemoglobin, total cholesterol, triglyceride, high-density lipoprotein, and low-density lipoprotein were estimated
among the cases and controls. The student`s t-test was used to compare the mean values.

Results: A statistically significant difference was observed in mean glycated hemoglobin, total cholesterol, triglyceride, high density lipoprotein and low-density lipoprotein among the cases and controls (p-value<0.05).

Conclusions: This study concluded that there was a significant difference in mean glycated hemoglobin, total cholesterol, triglyceride, high-density cholesterol, and low-density cholesterol among the cases and controls. It is suggestive that lipid profile must be considered among diabetic patients which could be beneficial to prevent the risk of cardiovascular complications.

Downloads

Download data is not yet available.
Abstract
41
PDF
12

Downloads

Published

2022-08-03

How to Cite

Yadav, T., Bhaskar, M. V., Bajracharya, J., Sharma, S. S. B., Maharjan, N., & Bhadeshwar, S. (2022). Study of Glycated Haemoglobin and Lipid Profile in Type-2 Diabetes Mellitus. Nepal Journal of Health Sciences, 2(1), 17–21. https://doi.org/10.3126/njhs.v2i1.47157

Issue

Section

Research Articles