Drug resistance pattern of Mycobacteria isolated from smear positive cases of pulmonary tuberculosis in eastern part of Nepal

Authors

  • Prasil Pradhan Lecturer, Department of Microbiology and Immunology, Patan Academy of Health Sciences, Lalitpur, Nepal.
  • Nimesh Poudyal B.P. Koirala Institute of Health Sciences, Dharan, Nepal.
  • Rajendra Gurung B.P. Koirala Institute of Health Sciences, Dharan, Nepal.
  • Anju Acharya Chitwan School of Medical Science, Chitwan, Nepal.
  • Shyamal Kumar Bhattacharya B.P. Koirala Institute of Health Sciences, Dharan, Nepal.

Keywords:

Drug resistance, mycobacterium, pulmonary tuberculosis

Abstract

Introduction: The emergence of drug resistance in tuberculosis has become a major challenge for effective control of tuberculosis. This study was done with an aim to determine the drug resistance pattern of mycobacteria isolated from pulmonary tuberculosis.
Methods: Sputum samples were collected from patients attending B.P. Koirala Institute of Health Sciences, Dharan during 1st June 2006 to 30th May 2007. The smear positive samples were cultured on Lowenstein Jensen medium and drug sensitivity was performed by proportion method.
Results: Among 202 Mycobacterial isolates, 96 (47.52%) were sensitive to all four drugs, 50 (24.75%) were resistant to single drug and 15 (7.42%) were MDR strains. Higher rate of MDR was seen in previously treated cases (15.51%) than in new cases (4.6%).
Conclusion: This study reflects a high burden of drug resistant tuberculosis in the eastern part of Nepal.

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Published

2014-06-30

How to Cite

Pradhan, P., Poudyal, N., Gurung, R., Acharya, A., & Bhattacharya, S. K. (2014). Drug resistance pattern of Mycobacteria isolated from smear positive cases of pulmonary tuberculosis in eastern part of Nepal. Journal of General Practice and Emergency Medicine of Nepal, 2(04), 7–12. Retrieved from https://nepjol.info/index.php/jgpemn/article/view/89718

Issue

Vol. 2 No. 04 (2014)

Section

Original Articles

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Copyright (c) 2014 The Author(s)

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