Antibiogram of Salmonella Spp Isolates in Kathmandu, Nepal

Authors

  • Damodar Gajurel Department of Medicine, Civil Service Hospital, Minbhawan, Kathmandu
  • Rabi Prakash Sharma Department of Medicine, Civil Service Hospital, Minbhawan, Kathmandu
  • Krishna Dhungana Department of Medicine, Civil Service Hospital, Minbhawan, Kathmandu
  • Samir Neupane Department of Medicine, Civil Service Hospital, Minbhawan, Kathmandu
  • Kamal Lamsal Department of Medicine, Civil Service Hospital, Minbhawan, Kathmandu
  • Prasant Karki Department of Medicine, Civil Service Hospital, Minbhawan, Kathmandu
  • Sudikshya Acharya Department of Medicine, Civil Service Hospital, Minbhawan, Kathmandu

DOI:

https://doi.org/10.3126/jucms.v5i2.19159

Keywords:

S. Typhi, S. Paratyphi A, Nalidixic-resistance, Fluoroquinolones

Abstract

INTRODUCTION: Drug resistant Salmonella spp. is endemic in several Asian countries. Nalidixic acid-resistant Salmonella enterica serovar Typhi and Salmonella enterica serovar Paratyphi A show reduced susceptibility to fluoroquinolones and have resulted in a rise in treatment failures. Over the past few decades, nalidixic acid-resistant Salmonella spp have emerged in Nepal as well.

MATERIAL & METHODS: This is a retrospective study that aims to provide a more recent antibiogram of S. Typhi and S. Paratyphi A isolates in Kathmandu. Between Poush, 2071 and Ashwin, 2072 (December 16, 2014 to October 17, 2015), 186 culture positive cases of enteric fever were diagnosed at the Civil Service Hospital. Upon isolation of S. Typhi or S. Paratyphi A, antimicrobial susceptibility testing was performed with amoxicillin, azithromycin, ceftriaxone, chloramphenicol, ciprofloxacin, cotrimoxazole, nalidixic acid, ofloxacin and tetracyciline.

RESULTS: This study shows a much higher frequency of nalidixic acid-resistance in Kathmandu than previously reported; 95.7% in Salmonella enterica serovar Paratyphi A and 86.5% in Salmonella enterica serovar Typhi.The rates of ciprofloxacinand ofloxacin-resistance were over 50% in both serovar.

CONCLUSION: In Nepal, it is necessary to reevaluate the use of fluoroquinolone therapy and introduce feasible alternatives so as to curb treatment failures.

Journal of Universal College of Medical Sciences (2017) Vol. 5, No, 2, Page: 22-25

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Published

2018-02-08

How to Cite

Gajurel, D., Sharma, R. P., Dhungana, K., Neupane, S., Lamsal, K., Karki, P., & Acharya, S. (2018). Antibiogram of Salmonella Spp Isolates in Kathmandu, Nepal. Journal of Universal College of Medical Sciences, 5(2), 22–25. https://doi.org/10.3126/jucms.v5i2.19159

Issue

Vol. 5 No. 2 (2017)

Section

Original Articles

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