Nanoprecipitation Based Preparation and Physicochemical Characterization of Flavonoid Nanoparticles

Authors

  • Kiran Prabhakar Sinkar Department of Pharmacognosy, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist. Dhule, Maharashtra, India
  • Piyush Shantilal Bafna Department of Pharmacognosy, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist. Dhule, Maharashtra, India
  • Rakesh Eshwarlal Mutha Department of Pharmacognosy, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist. Dhule, Maharashtra, India

DOI:

https://doi.org/10.3126/bdpr.v20i2.57028

Keywords:

Chrysin, Carrier, Nanoparticles, Nanoprecipitation technique, Polymer

Abstract

Out of different secondary metabolites, flavonoids attract the attention of researchers due to their pharmacological potential and health benefits. But solubility and bioavailability issues severely restrict their use. Development of nanoformulation of flavonoids is one of the solutions to overcome these issues. The purpose of this study was to develop and characterize chrysin (CHR) loaded nanoparticles (CHRNs) by nanoprecipitation technique with Eudragit® and polyvinyl alcohol (PVA) as carriers. Particle size, polydispersity index (PDI), zeta potential, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR) and X-ray powder diffraction (XRPD) was used to characterize the prepared CHRNs. The present study shows that CHRNs can be fabricated by a nanoprecipitation technique using the optimum weight ratio of CHR: Eudragit: PVA (1: 5: 5). The particle size, PDI, and zeta potential were found to be 238.1 nm, 0.434 and -20.1 mV. According to FTIR, CHR developed intermolecular hydrogen bonds with polymers (carriers). SEM imaging confirmed roughly spherical type particles with size of 100–400 nm. The results from the XRPD of the CHRNs showed that the crystal of the drug might be converted to an amorphous state. The release of the drug from the CHRNs was 85.54% compared with the pure drug at 45.11%.

Downloads

Download data is not yet available.
Abstract
19
PDF
37

Downloads

Published

2022-12-31

How to Cite

Sinkar, K. P., Bafna, P. S., & Mutha, R. E. (2022). Nanoprecipitation Based Preparation and Physicochemical Characterization of Flavonoid Nanoparticles. Journal of Plant Resources, 20(2), 139–145. https://doi.org/10.3126/bdpr.v20i2.57028