Role of Tranexamic acid in NSAIDS induced angioedema

Authors

  • Rupak Chalise Department of Critical Care Medicine, Nepal Mediciti Hospital
  • Saroj Poudel Department of Critical Care Medicine, Nepal Mediciti Hospital
  • Manoj Bist Department of Critical Care Medicine, Nepal Mediciti Hospital
  • Ashim Regmi Department of Critical Care Medicine, Nepal Mediciti Hospital
  • Anup Ghimire Department of Critical Care Medicine, Nepal Mediciti Hospital
  • Kishor Khanal Department of Critical Care Medicine, Nepal Mediciti Hospital

DOI:

https://doi.org/10.3126/nrj.v2i1.59613

Keywords:

Anaphylaxis, Non-allergic Anaphylaxis, Tranexamic acid, Angioedema

Abstract

Tranexamic acid (TXA) is an antifibrinolytic agent that inhibits the conversion of plasminogen to plasmin, a key step in kallikrein activation and bradykinin formation. Tranexamic acid is used in the prophylactic management of hereditary angioedema; however, evidence for TXA in Non-Steroidal Anti-inflammatory drug-induced angioedema (NSAIDS-AE) is limited. We describe a patient who presented to the ICU department with NSAIDS-AE and was successfully treated with TXA. This case suggests that TXA may be a beneficial treatment modality in the management of NSAIDS-AE and warrants further investigation.

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Published

2023-11-06

How to Cite

Chalise, R., Poudel, S., Bist, M., Regmi, A., Ghimire, A., & Khanal, K. (2023). Role of Tranexamic acid in NSAIDS induced angioedema. Nepalese Respiratory Journal, 2(1), 31–33. https://doi.org/10.3126/nrj.v2i1.59613

Issue

Section

Case Reports