Trajectory of pulmonary function parameters and radiology progress among patients with Idiopathic pulmonary fibrosis treated with Doxycycline

Authors

  • Subash S Heraganahally Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia
  • Timothy Howarth Darwin Respiratory and Sleep Health, Darwin Private Hospital, Darwin, Northern Territory, Australia
  • Himanshu Garg Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia

DOI:

https://doi.org/10.3126/nrj.v1i1.45301

Keywords:

Doxycycline, Idiopathic pulmonary fibrosis, Interstitial lung diseases, Pulmonary function test, Nintedanib, Pirfenidone

Abstract

Idiopathic pulmonary fibrosis is the most common and lethal form of interstitial lung diseases, with an associated median survival of only 2 to 3 years. Doxycycline through its matrix metalloproteinase inhibition property may be useful in slowing the disease progression among patients with ILD. However, there are only anecdotal reports in the literature in demonstrating long term trajectory in lung function parameters and radiology progress among IPF patients treated with doxycycline. In this report we describe the clinical course of two patients with IPF treated with doxycycline. We also compared the decline in the pulmonary function parameters in our patients with previously published predicted values for normal ageing (non-IPF), placebo, nintedanib and pirfenidone treated patients.

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Author Biographies

Subash S Heraganahally, Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia

Flinders University - College of Medicine and Public Health, Adelaide, South Australia, Australia.
Darwin Respiratory and Sleep Health, Darwin Private Hospital, Darwin, Northern Territory, Australia.

Timothy Howarth, Darwin Respiratory and Sleep Health, Darwin Private Hospital, Darwin, Northern Territory, Australia

College of Health and Human Sciences, Charles Darwin University, Darwin, Northern Territory, Australia

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Published

2022-05-23

How to Cite

Heraganahally, S. S., Howarth, T., & Garg, H. (2022). Trajectory of pulmonary function parameters and radiology progress among patients with Idiopathic pulmonary fibrosis treated with Doxycycline. Nepalese Respiratory Journal, 1(1), 35–39. https://doi.org/10.3126/nrj.v1i1.45301

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Section

Case Series