Anti-depressant Activity of the Seeds of Zanthoxylum armatum on Swiss Albino Mice

Authors

  • Chandrajeet Kumar Yadav Department of Pharmacology, Universal College of Medical Sciences, Bhairahawa, Nepal
  • Kamal Poudel Department of Pharmacology, Universal College of Medical Sciences, Bhairahawa, Nepal
  • Amit Shrivastava Department of Pharmacology, Universal College of Medical Sciences, Bhairahawa, Nepal
  • Roshan Mehta Department of Pharmacology, Universal College of Medical Sciences, Bhairahawa, Nepal
  • Tapeshwar Yadav Department of Laboratory Medicine, Madan Bhandari Academy of Health Sciences, Hetauda, Nepal

DOI:

https://doi.org/10.3126/njhs.v2i1.47173

Keywords:

Anti-depressant activity, imipramine, methanolic extracts, zanthoxylum armatum

Abstract

Introduction: Depression disorder has significant potential morbidity and mortality, contributing to suicide, incidence and adverse outcomes of medical illness, disruption in interpersonal relationships, substance abuse, and lost work time.

Objectives: The present study was designed to study the anti-depressant activity of the seeds extract of Zanthoxylum armatum using a forced swim test and tail suspension test on Swiss albino mice. The anti-depressant activity of the seeds of Zanthoxylum armatum was assessed using Chronic Unpredictable Mild-Stress (CUMS) induced depression in mice.

Methods: The animals were treated with the methanolic extract of seeds of Zanthoxylum armatum orally at two doses of 100, 200mg/kg body weight for eight days after CUMS induced depression in mice. The results demonstrate that Methanolic extract of seeds of Zanthoxylum armatum has got anti-depressant potential.

Results: The study showed that the extract of Zanthoxylum armatum had significant antidepressant activity. Microsoft Excel was used to calculate the mean ± SEM and one-way ANOVA followed by a turkey multiple comparison test was used to analyze the results. The seed extract presented significant antidepressant activity in mice (p<0.05).

Conclusions: This study was conducted to explore the antidepressant activity of seeds extracts of plant Zanthoxylum armatum in CUMS induced mice.

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Published

2022-08-03

How to Cite

Yadav, C. K., Poudel, K., Shrivastava, A., Mehta, R., & Yadav, T. (2022). Anti-depressant Activity of the Seeds of Zanthoxylum armatum on Swiss Albino Mice. Nepal Journal of Health Sciences, 2(1), 98–103. https://doi.org/10.3126/njhs.v2i1.47173

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Section

Research Articles