Primary studies on biotransformation of steroidal drug Prednisolone

Authors

  • Meghmala Sheshrao Waghmode PDEA’s Annasaheb Magar Mahavidyalaya, Hadapsar, Pune-411028 https://orcid.org/0000-0002-5635-134X
  • Vrishali Rajendra Bankar PDEA’s Annasaheb Magar Mahavidyalaya, Hadapsar, Pune-411028
  • Ankita Subhash Gaikwad PDEA’s Annasaheb Magar Mahavidyalaya, Hadapsar, Pune-411028
  • Priti Vitthal Gaikwad PDEA’s Annasaheb Magar Mahavidyalaya, Hadapsar, Pune-411028
  • Neha Nitin Patil PDEA’s Annasaheb Magar Mahavidyalaya, Hadapsar, Pune-411028 https://orcid.org/0000-0003-1228-6475

DOI:

https://doi.org/10.3126/njes.v10i1.40538

Keywords:

Klebsiella, pollutant, prednisolone, transformation

Abstract

The less biodegradable steroidal drug, Prednisolone is one of the widely used drugs in the treatment of autoimmune and infectious diseases. Transformation of prednisolone can be achieved with microbial activity. Isolation of prednisolone-resistant microorganisms was done using a sewage sample. Out of 5 isolates, one isolate was selected for further studies based on maximum tolerability to prednisolone. The isolate was identified based on MALDI-TOF. The strain was found to have a match score of 2.336 with gram-negative bacteria Klebsiella pneumoniae spp pneumoniae DSM3010 4T HAM. The isolate was found to degrade 80% prednisolone on the 5th day of fermentation. The concentration of prednisolone was determined using a colorimetric-based method and HPLC technique.

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Published

2022-07-12

How to Cite

Waghmode, M. S., Bankar, V. R., Gaikwad , A. S., Gaikwad, P. V., & Patil, N. N. (2022). Primary studies on biotransformation of steroidal drug Prednisolone. Nepal Journal of Environmental Science, 10(1), 1–6. https://doi.org/10.3126/njes.v10i1.40538

Issue

Section

Research Articles