Correlations of hepatorenal functions among Diabetes patients attending tertiary care centers at Janakpurdham

Authors

  • Satyam Prakash Department of Biochemistry, Janaki Medical College, Tribhuvan University, Nepal https://orcid.org/0000-0002-3894-7123
  • Manohar Kumar Sah Department of Clinical Pathology, Ram Janaki Hospital, Janakpurdham, Nepal
  • Vijay Kumar Sah Department of Internal Medicine, Janaki Medical College, Tribhuvan University, Nepal
  • Om Prakash Yadav Department of Physiology, Janaki Medical College, Tribhuvan University, Nepal
  • Ramesh Nayak Department of Physiology, Janaki Medical College, Tribhuvan University, Nepal
  • Buddharam Yadav Department of Clinical pathology, Janaki Medical College, Tribhuvan University, Nepal

DOI:

https://doi.org/10.3126/mjmms.v3i6.66614

Keywords:

Aspartate aminotransferase , alanine aminotransferase, creatinine, diabetes, hepatorenal, urea , fasting blood sugar

Abstract

INTRODUCTION: Diabetes mellitus (DM) has multiple long-term consequences linked to hepatorenal pathophysiology. The long-term DM is associated with evidences of abnormal liver and renal function. However, this yet to be clearly established, especially in rural low to mid-income countries like Nepal. Thus, we aimed to assess correlations of hepatorenal functions among diabetes patients attending tertiary care centers at Janakpurdham, Nepal.

MATERIALS AND METHODS: A total of 227 diabetes patients attending medicine OPD of Janaki Medical College teaching hospital, Ramdiaya and Ram Janaki Hospital, Janakpur were enrolled. Under aseptic conditions, blood samples were collected. Semi-automatic analyzers were used for all biochemical investigations. Pearson correlation test was used to observe correlation between the various hepatorenal functions in diabetic patients. A p-value less than 0.005 was considered to be significant.

RESULTS: Out of total 227 diabetes patients, 132 (58.1%) were male and 95 (41.9%) were female. Significant results were obtained regarding the correlation between the hepatic and renal profile with SGOT [SGPT (p=0.000); Urea (p=0.049)]. Significant correlations were found between the liver and renal profile with SGPT [Albumin (p=0.050); Creatinine (p=0.020)] and with urea [Creatinine (p=0.000)]. Similarly, there was a significant correlation between the renal profile and liver with urea [Creatinine (p=0.000)] and for creatinine [Sodium (p=0.000)].

CONCLUSIONS: Among diabetic patients, there was a substantial correlation between the liver and renal profiles. The etiology of various forms of diabetes mellitus is significantly influenced by hepatorenal factors among diabetics.

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Published

2023-12-31

How to Cite

Prakash, S., Sah, M. K., Sah, V. K., Yadav, O. P., Nayak, R., & Yadav, B. (2023). Correlations of hepatorenal functions among Diabetes patients attending tertiary care centers at Janakpurdham. MedS Alliance Journal of Medicine and Medical Sciences, 3(6), 77–83. https://doi.org/10.3126/mjmms.v3i6.66614

Issue

Section

Original Investigations