Serum Bilirubin and Uric Acid Levels in Pan Masala Tobacco Users as Compared to Non-Users

Authors

  • Buddhi Raj Pokhrel Department of Biochemistry, Universal College of Medical Sciences, Bhairahawa, Nepal https://orcid.org/0000-0001-7947-2913
  • Samjhana KC Lumbini Province, Ministry of Health, Population and Family Welfare, Rapti Upatyaka (Deukhuri), Dang, Nepal
  • Archana Jayan Department of Biochemistry, Universal College of Medical Sciences, Bhairahawa, Nepal
  • Jharana Shrestha Department of Biochemistry, Universal College of Medical Sciences, Bhairahawa, Nepal
  • Binaya Tamang Department of Biochemistry, Universal College of Medical Sciences, Bhairahawa, Nepal
  • Narayan Gautam Department of Biochemistry, Universal College of Medical Sciences, Bhairahawa, Nepal
  • Amit Chandra Jha Department of Biochemistry, National Medical College, Birgunj, Nepal
  • Raju Kumar Dubey Department of Biochemistry, Institute of Medicine, Kathmandu, Nepal

DOI:

https://doi.org/10.3126/mjmms.v2i4.53529

Keywords:

Bilirubin, Oxidative stress, Pan Masala Tobacco, Uric acid

Abstract

INTRODUCTION: Pan Masala Tobacco (PMT), consumed in smoke and smokeless form, contains various carcinogenic chemicals and free radicals. Bilirubin and uric acid are said to have both pro- and anti-oxidant activities. In this context, we aimed to compare the serum levels of bilirubin and uric acid between PMT users and non-users. We also wanted to observe the pattern of PMT consumption among the users. MATERIALS AND METHODS: A total of 204 participants were enrolled in this community-based comparative cross-sectional study. The study was conducted in the Ranigaun community, Rupandehi, Nepal, from March 2020 to December 2020 AD for ten months. Serum bilirubin (total, conjugated and unconjugated) and uric acid levels of both PMT users (n = 103) and non-users (n = 101) were measured. MannWhitney U test and Chi-squared analysis were performed. A p-value of < 0.05 was considered statistically significant. RESULTS: The majority of PMT users were male (n= 90; 87.3%). Most of them consumed smokeless forms of PMT (n = 64; 62.1%), with tobacco being the most preferred product (n = 42; 40.8%). The average age of PMT users was significantly higher (44 years) than the non-users (38 years). The serum uric acid and bilirubin levels were not significantly different among the PMT users and non-users. CONCLUSIONS: Male consumed more PMT than females. Smokeless tobacco was the most preferred product in the studied area. Serum bilirubin and uric acid levels did not vary significantly between PMT users and non-users.

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Published

2022-12-31

How to Cite

Pokhrel, B. R., KC, S., Jayan, A., Shrestha, J., Tamang, B., Gautam, N., Jha, A. C., & Dubey, R. K. (2022). Serum Bilirubin and Uric Acid Levels in Pan Masala Tobacco Users as Compared to Non-Users. MedS Alliance Journal of Medicine and Medical Sciences, 2(4), 21–25. https://doi.org/10.3126/mjmms.v2i4.53529

Issue

Section

Original Investigations