Adherence to Anti-tubercular Agents in DOTS Center in Western Nepal

Authors

  • Anjan Palikhey Department of Pharmacology, Universal College of Medical Sciences, Tribhuvan University, Bhairahawa, Nepal https://orcid.org/0000-0002-0224-0791
  • Dil Kapoor Kohar Department of Pharmacy, Unversal College of Medical Sciences, Bhairahawa, Nepal
  • Amit Kumar Shrivastava Department of Pharmacology, Universal College of Medical Sciences, Tribhuvan University, Bhairahawa, Nepal
  • Jharana Shrestha Department of Biochemistry, Unversal College of Medical Sciences, Bhairahawa, Nepal
  • Laxmi Shrestha Department of Pharmacology, Universal College of Medical Sciences, Tribhuvan University, Bhairahawa, Nepal
  • Chandrajeet Kumar Yadav Department of Pharmacology, Universal College of Medical Sciences, Tribhuvan University, Bhairahawa, Nepal
  • Jyoti Priyanka Department of Community Medicine, Unversal College of Medical Sciences, Bhairahawa, Nepal
  • Lokeshwar Chaurasia Department of Pharmacology, Janaki Medical College, Tribhuvan University, Janakpur, Nepal https://orcid.org/0000-0001-6561-4642
  • Dipendra Chaudhary Department of Pharmacy, Lumbini Provincial Hospital, Butwal, Nepal

DOI:

https://doi.org/10.3126/mjmms.v2i3.47654

Abstract

INTRODUCTION: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis and is one of the major public health problems in developing countries like Nepal. Despite the availability of effective tuberculosis treatment regimens, patients must take a combination of anti-tubercular drugs for at least six months and may endure numerous side effects, making treatment compliance exceedingly difficult to maintain. The primary objective of the study was to assess the adherence rate to anti-tubercular agents and to find the prevalence of adverse drug reactions to the anti-tubercular therapy.

MATERIALS AND METHODS: This study was an observational study conducted in the DOTS centers of UCMS-TH, Bhairahawa, and Lumbini Provincial Hospital Butwal. A semi-structured questionnaire was used to collect data from 170 participants to determine the adherence rate to anti-tubercular therapy and the incidence of associated adverse drug reactions. Statistical Package for Social Sciences (SPSS Version 20) program was used to enter and analyze the data. The association between adherence and other variables was established using the Chisquare test.

RESULTS: The adherence rate to anti-tubercular therapy was found to be 159 (93.5%). The major reasons for non-adherence include forgetfulness 8 (72.72%) followed by adverse effects 2 (18.18%) and transport difficulty in reaching the health facility 1 (9.1%). The prevalence of adverse drug reactions was 58 (34.12%) (27.1 - 41.2 at 95% Confidence Interval). Adherence was significantly associated with the experience of adverse effects, literacy, marital status, area of residence, and age of the participants.

CONCLUSIONS: The adherence rate to anti-tubercular therapy was very high, which can be the primary determinant of tuberculosis treatment success.

Downloads

Download data is not yet available.
Abstract
82
PDF
56

Downloads

Published

2022-08-20

How to Cite

Palikhey, A., Kohar, D. K., Shrivastava, A. K., Shrestha, J., Shrestha, L., Yadav, C. K., Priyanka, J., Chaurasia, L., & Chaudhary, D. (2022). Adherence to Anti-tubercular Agents in DOTS Center in Western Nepal. MedS Alliance Journal of Medicine and Medical Sciences, 2(3), 6–11. https://doi.org/10.3126/mjmms.v2i3.47654

Issue

Section

Original Investigations