Diagnostic Dilemma of Hemolytic Anemia: A Reveal Secondary to Gastric Adenocarcinoma

Authors

  • Prerana Gautam Department of Pathology, B & C Medical College Teaching Hospital and Research Center, Birtamode, Jhapa, Nepal https://orcid.org/0009-0002-8391-8484
  • Ishwor Man Singh Department of Hematology, B & C Medical College Teaching Hospital and Research Center, Birtamode, Jhapa, Nepal
  • Bimas Payangu Limbu Department of Surgery, B & C Medical College Teaching Hospital and Research Center, Birtamode, Jhapa, Nepal
  • Monasha Vaidya Department of Pathology, B & C Medical College Teaching Hospital and Research Center, Birtamode, Jhapa, Nepal
  • Ujwal Rai Department of Pathology, B & C Medical College Teaching Hospital and Research Center, Birtamode, Jhapa, Nepal

DOI:

https://doi.org/10.3126/mjen.v2i01.56222

Keywords:

Chemotherapy, Coombs test, CR-MAHA-Cancer related MAHA, MAHA-microangiopathic hemolytic anemia, Metastatic adenocarcinoma, Signet ring cells

Abstract

Here is a case report of a 62-year-old female who presented to our hospital with complaints of abdominal pain, unresolving severe anemia, bleeding per rectum with history of multiple blood transfusions at outside hospital. On initial investigations, the findings directed towards case of hemolytic anemia. The cause of hemolytic anemia was still unknown even after extensive clinical and laboratory investigations. Bone marrow biopsy was done, which revealed metastatic adenocarcinoma and diagnosis of cancer-related microangiopathic haemolytic anaemia (CR-MAHA) was established. Endoscopic biopsy was done from gastric growth which revealed gastric adenocarcinoma and final diagnosis of microangiopathic hemolytic anemia secondary to gastric adenocarcinoma was made.

The patient’s haematological parameters improved with chemotherapy directed against the gastric adenocarcinoma. Our case supports the findings of various literature which indicates that the gastric cancer-associated MAHA responds well to the treatment with chemotherapy for primary carcinoma.

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Published

2023-06-30

How to Cite

Gautam, P., Singh, I. M., Limbu, B. P., Vaidya, M., & Rai, U. (2023). Diagnostic Dilemma of Hemolytic Anemia: A Reveal Secondary to Gastric Adenocarcinoma. Medical Journal of Eastern Nepal, 2(01), 44–46. https://doi.org/10.3126/mjen.v2i01.56222

Issue

Section

Case Reports