Histopathological Pattern of Gynecological Malignancy at Tribhuvan University Teaching Hospital, Nepal

Abstract

Aims: This study aims to find out histopathological diagnosis and stage at presentation during the diagnosis of female genital tumors.

Methodology: This is hospital based prospective observational study of histopathologically confirmed gynecological malignancies conducted in the Department of Obstetrics and Gynecology, TUTH, Maharajgunj, Kathmandu for one year from 2014 to 2015

Results: Among 102 cases enrolled in the study, the most common gynecological malignancy was of ovary (48%) followed by cervix (31%), endometrium (11%), vulval (6%), gestational trophoblastic neoplasia (3%) and fallopian tube (1%). Patients presented in early stage in 66.6% of cases. Seventy-nine percent of ovarian cancer, 96.8% cases of cervical carcinoma, 66.6% cases of gestational trophoblastic neoplasia and all the cases of the endometrial, vulval fallopian tube carcinoma presented in early stage of the disease. The most common histopathological diagnosis of ovarian cancer was serous cyst adenocarcinoma (49.4%), cervical cancer was squamous cell nonkeratinising type (72%), endometrial carcinoma was endometroid adenocarcinoma (82%), vulval carcinoma were squamous cell carcinoma (100%) and fallopian tube carcinoma was adenocarcinoma (100%). The mean age of gynecological malignancy was 49.6±14.5 years.

Conclusions: Screening of gynecological malignancy in women with suggestive symptoms is necessary to identify this disease in early stage and decrease the incidence, morbidity and mortality from this common public health problem.