Incidental Inguinal Tubercular Lymphadenitis in a female of Androgen Insensivity Syndrome- A rarest of rare presentation

Authors

  • Paridhi Government Institute of Medical Sciences, India
  • Shalini Bahadur Government Institute of Medical Sciences, India
  • Madhuvan Gupta Government Institute of Medical Sciences, India https://orcid.org/0000-0002-7896-7823
  • Shalini Shukla Government Institute of Medical Sciences, India
  • Shivani Kalhan Government Institute of Medical Sciences, India
  • Deepak Goel Government Institute of Medical Sciences, India
  • Deeksha Singh Government Institute of Medical Sciences, India
  • Vivek Gupta Government Institute of Medical Sciences, India

DOI:

https://doi.org/10.3126/jpn.v13i1.51477

Keywords:

Androgen insensitivity syndrome, Tubercular lymphadenitis, Inguinal tuberculosis, testicular feminization, disorder of sex development, Ambiguous genitalia

Abstract

Androgen insensitivity syndrome (AIS) is a rare X-linked recessive disorder occurring in phenotypic women with male genotype (46, XY) resulting due to mutation in the X chromosome. On the other hand, tuberculosis (TB) is a chronic granulomatous infection caused by Mycobacterium tuberculosis, an acid-fast bacillus. We report a case of a 22-year-old unmarried female presenting with bilateral inguinal pain and primary amenorrhea, which, on comprehensive evaluation, revealed complete female external genitalia and intra-abdominal testes. The karyotype was 46 XY, hence a diagnosis of complete AIS was made. One of the ‘probable testes’ removed surgically was an inguinal lymph node with tuberculous lymphadenitis. Isolated inguinal tuberculous lymphadenopathy, by itself, is rare. Co-occurrence of Complete AIS and inguinal tuberculous lymphadenopathy is a highly unusual and rare association that has not been documented in the literature reviewed.

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Author Biographies

Paridhi, Government Institute of Medical Sciences, India

Senior Resident, Department of Pathology

Shalini Bahadur, Government Institute of Medical Sciences, India

Professor, Department of Pathology

Madhuvan Gupta, Government Institute of Medical Sciences, India

Department of Pathology

Shalini Shukla, Government Institute of Medical Sciences, India

Department of Pathology

Shivani Kalhan, Government Institute of Medical Sciences, India

Department of Pathology

Deepak Goel, Government Institute of Medical Sciences, India

Department of Pathology

Deeksha Singh, Government Institute of Medical Sciences, India

Department of Pathology

Vivek Gupta, Government Institute of Medical Sciences, India

Department of Pathology

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Published

2023-07-12

How to Cite

Paridhi, Bahadur, S., Gupta, M., Shukla, S., Kalhan, S., Goel, D., Singh, D., & Gupta, V. (2023). Incidental Inguinal Tubercular Lymphadenitis in a female of Androgen Insensivity Syndrome- A rarest of rare presentation. Journal of Pathology of Nepal, 13(1), 2022–2025. https://doi.org/10.3126/jpn.v13i1.51477

Issue

Section

Case Reports

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