Synthesis of 4-Aryl-3-ethoxycarbonyl-1-oxo-1,2,3,4-tetrahydronaphthalene: An Imporant Frame Work in Lignan Family

Authors

  • Ashok Kumar Singh Department of Chemistry Tri-Chandra Multiple Campus Tribhuvan University

DOI:

https://doi.org/10.3126/jncs.v27i1.6666

Keywords:

Lignans, tetralins, tetralones Benzophenone, 4-Aryl-3-ethoxycarbonyl-1-oxo-1, 2, 3, 4-tetrahydronaphthalene

Abstract

4,4-diaryl-3-ethoxycarbonyl-3-butenoic acid (2a-d, Scheme 1) has been synthesized by Stobbe condensation of substituted benzophenones 1a-d with t-potassium butoxide and diethyl succinate. Compounds 2a-d on reduction with sodium amalgum furnished 4,4-diaryl-3-ethoxycarbonyl-3-butanoic acid 3a-d, which on intramolecular cyclization with polyphosphoric acid gave target compounds 4-aryl-3-ethoxycarbonyl-1-oxo--1,2,3,4-tetrahydronaphthalene 4a-d.

DOI: http://dx.doi.org/10.3126/jncs.v27i1.6666

J. Nepal Chem. Soc., Vol. 27, 2011 86-93

 

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Published

2012-08-22

How to Cite

Singh, A. K. (2012). Synthesis of 4-Aryl-3-ethoxycarbonyl-1-oxo-1,2,3,4-tetrahydronaphthalene: An Imporant Frame Work in Lignan Family. Journal of Nepal Chemical Society, 27(1), 86–93. https://doi.org/10.3126/jncs.v27i1.6666

Issue

Vol. 27 (2011)

Section

Articles

License

© Journal of Nepal Chemical Society