Role of Vyoshadi Guggulu and Tiktaksheera Basti in the Management of Janu Sandhigatavata (Osteoarthritis Knee)

Abstract

Osteoarthritis (OA) is a degenerative joint disorders which remains a primary contributor to chronic pain, disability, and impaired mobility among adults and elderly populations globally. Despite advances in modern medicine, current treatment modalities for osteoarthritis remain largely palliative and lack a definitive cure. In Ayurveda, OA is correlated with Sandhigatavata, a condition rooted in the vitiation of Vata Dosha and depletion of Asthi Dhatu. The osteoarthritis of Knee joint is correlated with Janusandhigatavata. This study was aimed to assess the therapeutic efficacy of Vyoshadi Guggulu and Tiktaksheera Basti, individually and in combination, for the management of Janu Sandhigatavata. 45 clinically diagnosed OA patients participated in the study which were equally assigned into three groups being Group A (Vyoshadi Guggulu), Group B (Tiktaksheera Basti), and Group C (combination therapy) respectively. Assessments included parameters such as Pain, stiffness, swelling, crepitus, functional mobility, WOMAC scores, hematological, renal function tests, and radiological examinations. All treatment groups exhibited significant symptomatic improvement, while the combination therapy group demonstrated better overall relief. No adverse reactions or biochemical abnormalities were observed. The study concludes that Vyoshadi Guggulu and Tiktaksheera Basti are effective and safe in the management of Janu Sandhigatavata.