Malignant Hyperthermia in a 2-Year-Old Following General Anesthesia: A Rare Case Report from Nepal

Authors

  • Bikash Khadka Anesthesia and Critical Care, Dept. of Anesthesia and Pain Management, Nepal Mediciti, Nakhu, Nepal
  • Kishor Khanal Anesthesia and Critical Care, Dept. of Anesthesia and Pain Management, Nepal Mediciti, Nakhu, Nepal
  • Prajjwal Raj Bhattarai Anesthesia and Critical Care, Dept. of Anesthesia and Pain Management, Nepal Mediciti, Nakhu, Nepal
  • Saurav Khatiwada MD Anesthesia Resident, Dept. of Anesthesia and Pain Management, Nepal Mediciti, Nakhu, Nepal
  • Saroj Poudel Clinical Pharmacist, Nepal Mediciti, Nakhu, Nepal
  • Prabal Tiwari MBBS, Kathmandu University School of Medical Sciences, Dhulikhel, Nepal
  • Pratikshya Timalsina MBBS, Kathmandu University School of Medical Sciences, Dhulikhel, Nepal
  • Bijay GC MBBS, Lumbini Medical College and Teaching Hospital, Palpa, Nepal

DOI:

https://doi.org/10.3126/nmmj.v6i1.81108

Keywords:

Dantrolene, Inhaled anesthetics, Isoflurane, Malignant Hyperthermia

Abstract

Malignant hyperthermia (MH) is a pharmacogenetic disorder triggered by inhaled anesthetics or depolarizing muscle relaxants, leading to a catabolic state of skeletal muscle. Key clinical signs include tachycardia, hyperthermia, muscle rigidity, hypercapnia, acidosis, rhabdomyolysis, hyperkalemia, and renal failure. Without prompt and specific treatment, the mortality rate can reach 80%. However, early recognition and the administration of dantrolene sodium can reduce this rate to 5%. This article presents the case of a 2-year-old male patient admitted to the Intensive Care Unit with suspected MH following surgery for a crush injury to his left hand, which was performed under general anesthesia.

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Published

2025-07-04

How to Cite

Khadka, B., Khanal, K., Bhattarai, P. R., Khatiwada, S., Poudel, S., Tiwari, P., … GC, B. (2025). Malignant Hyperthermia in a 2-Year-Old Following General Anesthesia: A Rare Case Report from Nepal. Nepal Mediciti Medical Journal, 6(1), 23–28. https://doi.org/10.3126/nmmj.v6i1.81108

Issue

Vol. 6 No. 1 (2025)

Section

Case Reports

License

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