Association of serum 25-hydroxyvitamin D in COVID-19: A study from India

Authors

  • Samala Naveenreddy Yashoda hospital Somajiguda Hyderabad-500082 India
  • Jaydip Ray Chaudhuri Yashoda hospital Somajiguda Hyderabad-500082 India
  • Kandadai Rukmini Mridula Nizam’s Institution of Medical Sciences Panjagutta Hyderabad-500082 India
  • Banda Balaraju Yashoda hospital Somajiguda Hyderabad-500082 India
  • VCS Srinivasarao Bandaru Yashoda hospital Somajiguda Hyderabad-500082 India

DOI:

https://doi.org/10.3126/nmmj.v2i1.37218

Keywords:

COVID-19, Vitamin D, CRP, D-dimer, Outcome

Abstract

Background: Novel coronavirus infection 2019 (COVID-19), a pandemic has affected patients irrespective of gender and age. Existing studies have incriminated low levels of serum 25-hydroxyvitamin D to be associated with COVID-19 infection. The present study was to investigate serum 25-hydroxyvitamin D levels in patients with COVID-19 infection.

Methods: We recruited prospectively 175 consecutive COVID-19 patients from the Department of Medicine, Yashoda hospital Hyderabad during the study period from May 2020 to December 2020. We measured in all patients, serum levels of 25-hydroxyvitamin D, calcium, phosphorus, alkaline phosphatase, C-reactive protein (CRP), D-Dimer, interleukin-6, procalcitonin, and ferritin.

Results: Out of 175 patients 122(69.7%) were men, mean age was 57.2±13.6 years. Clinical symptoms were fever in 175 (100%) dry cough in 110(62.8%), tiredness in 105(60%), shortness of breath in 94(53.7%), and mechanical ventilator support requirement at admission in 40(22.8%). Serum 25-hydroxyvitamin D deficiency was noted in 108(61.7%), CRP was positive in 119(68%), abnormal D-dimer levels in 96(54.8%), abnormal procalcitonin levels in 107(61.1%) abnormal interleukin-6 levels in 98(56%), abnormal serum ferritin levels in 106 (60.5%) and overall mortality in 13(7.4%). Older age (p =0.006) hypertension (p=0.02), diabetes (p=0.01), CRP positivity (p< 0.0001) and mortality (p=0.03) were significantly associated with serum25-hydroxyvitamin D deficiency in COVID-19 patients. Serum 25-hydroxyvitamin D deficiency and age >60 years were significant predictors of mortality with odds of 7.4; (95%CI: 1.10-56.36) and 2.8: (95%CI: 0.81-9.50) respectively.

Conclusion: In our study, serum 25-hydroxyvitamin D deficiency was seen in 61.1%, low levels of serum 25-hydroxyvitamin D was independently associated with >60 years age group and mortality in COVID-19.

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Author Biographies

Samala Naveenreddy, Yashoda hospital Somajiguda Hyderabad-500082 India

Department of Medicine

Jaydip Ray Chaudhuri, Yashoda hospital Somajiguda Hyderabad-500082 India

Department of Neurology

Kandadai Rukmini Mridula, Nizam’s Institution of Medical Sciences Panjagutta Hyderabad-500082 India

Department of Neurology

Banda Balaraju, Yashoda hospital Somajiguda Hyderabad-500082 India

Department of Medicine

VCS Srinivasarao Bandaru, Yashoda hospital Somajiguda Hyderabad-500082 India

Department of Medicine and Department of Clinical Research

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Published

2021-05-21

How to Cite

Naveenreddy, S., Chaudhuri, J. R., Mridula, K. R., Balaraju, B., & Bandaru, V. S. (2021). Association of serum 25-hydroxyvitamin D in COVID-19: A study from India. Nepal Mediciti Medical Journal, 2(1), 26–33. https://doi.org/10.3126/nmmj.v2i1.37218

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Original Articles