Short-term Effect of Garlic Extract on Patients with Dyslipidemia

Authors

  • A Limbu Department of Clinical Pharmacology and Therapeutics, BPKIHS, Dharan https://orcid.org/0000-0002-1666-2514
  • GP Rauniar Department of Clinical Pharmacology and Therapeutics, BPKIHS, Dharan
  • SK Sharma Department of Internal Medicine, BPKIHS, Dharan
  • DR Panday Department of Clinical Pharmacology and Therapeutics, BPKIHS, Dharan
  • BK Shah Department of Internal Medicine, BPKIHS, Dharan
  • M Subedi Department of Internal Medicine, BPKIHS, Dharan

DOI:

https://doi.org/10.3126/nmcj.v21i4.27626

Keywords:

Triglycerides, HDL, LDL, VLDL, Garlic, Total cholesterol

Abstract

Dyslipidemia is a metabolic abnormality leading to a persistent increase in the plasma concentration of cholesterol and triglycerides. Dyslipidemia is known to promote atherosclerosis. It is a complex disease and is a major risk factor for adverse cardiovascular events. Allium sativum commonly known as garlic has been found to have several medicinal value including, lipid-lowering property, blood pressure decreasing, anti-diabetic, anti-cancer and anti-oxidant activity. It was a double-blind, two-parallel-group, prospective interventional clinical trial. Total no of 112 patients were enrolled in the study and divided into two equal groups (56 in each group) viz; Group 1 (Lasuna TM) and Group 2 (placebo). Lipid profile was measured at day 0 and 90. Independent–sample‘t’ test was applied to find out the significant difference between the two groups, P-value being 0.05. The mean difference Total Serum Cholesterol, Serum Triglyceride, Serum LDL Cholesterol and Serum VLDL cholesterol on day 0 was nonsignificant with p being 0.539, 0.811, 0.230, 0.770 and 0.811 and on 90th day was significantly lower in group taking garlic with p being 0.001, 0.014, 0.003 and 0.008 respectively whereas Serum HDL cholesterol on 90th day was significantly higher in group taking garlic with p being 0.001. Garlic, when given as supplement decreases Total Serum Cholesterol, Serum Triglycerides, Serum LDL Cholesterol and Serum VLDL Cholesterol and on the other hand it increases Serum HDL Cholesterol.

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Published

2019-12-31

How to Cite

Limbu, A., Rauniar, G., Sharma, S., Panday, D., Shah, B., & Subedi, M. (2019). Short-term Effect of Garlic Extract on Patients with Dyslipidemia. Nepal Medical College Journal, 21(4), 301–305. https://doi.org/10.3126/nmcj.v21i4.27626

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Section

Original Articles