Clinicopathological profile of Papillary thyroid carcinoma in a tertiary cancer hospital in Nepal

Authors

  • Samyam Parajuli Head and Neck Unit, Dept of Surgical Oncology, B. P. Koirala Memorial Cancer Hospital, Bharatpur, Nepal
  • Dej Kumar Gautam Head and Neck Unit, Dept of Surgical Oncology, B. P. Koirala Memorial Cancer Hospital, Bharatpur, Nepal
  • Anil Bikram Karki Head and Neck Unit, Dept of Surgical Oncology, B. P. Koirala Memorial Cancer Hospital, Bharatpur, Nepal
  • Dilip Karmacharya Head and Neck Unit, Dept of Surgical Oncology, B. P. Koirala Memorial Cancer Hospital, Bharatpur, Nepal
  • Amar Shrestha Head and Neck Unit, Dept of Surgical Oncology, B. P. Koirala Memorial Cancer Hospital, Bharatpur, Nepal
  • Bijay Neupane Head and Neck Unit, Dept of Surgical Oncology, B. P. Koirala Memorial Cancer Hospital, Bharatpur, Nepal
  • Greta Pandey Dept of Pathology, B P Koirala Memorial Cancer Hospital, Bharatpur, Nepal
  • Kamana Chalise Head and Neck Unit, Dept of Surgical Oncology, B. P. Koirala Memorial Cancer Hospital, Bharatpur, Nepal
  • Subash Devkota Head and Neck Unit, Dept of Surgical Oncology, B. P. Koirala Memorial Cancer Hospital, Bharatpur, Nepal

DOI:

https://doi.org/10.3126/njc.v7i1.60034

Keywords:

papillary thyroid carcinoma, demographic profile, treatment modalities, clinicopathological characteristics

Abstract

Background: Differentiated thyroid cancers (DTC), including papillary thyroid carcinoma (PTC), are on the rise. This study provides a detailed examination of PTC cases in a tertiary care cancer hospital in Nepal, aiming to understand its clinical characteristics and treatment patterns. We conducted a retrospective analysis of PTC, including demographics, features of tumor, and treatment modalities.

Methods: A retrospective cross-sectional study assessed cases of PTC from January 2022 to December 2022. Patient data were collected and analyzed, focusing on demographics, tumor attributes, and treatment approaches.

Results: Among 105 patients, females were predominant (female-to-male ratio 5.2:1), and ethnic diversity was observed. Most patients were from Lumbini Pradesh. The mean age was 40.78 years. Fine-needle aspiration cytology (FNAC) showed Bethesda VI as the most common classification. Primary treatment involved total thyroidectomy (76.25%). Classical PTC was the major histopathological variant (78.1%). Tumors were frequently located in the right lobe (55.25%). Unifocal tumors were prevalent (74.28%), with an average size of 2.74 cm. Lymph node metastasis occurred in 49.5% of patients. Intermediate-risk patients constituted the majority (53.5%).

Conclusion: This study offers crucial insights into PTC's clinical spectrum in Nepal, aiding in tailored patient care strategies. The findings contribute to informed decision-making for enhanced treatment outcomes.

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Published

2023-11-28

How to Cite

Parajuli, S., Gautam, D. K., Karki, A. B., Karmacharya, D., Shrestha, A., Neupane, B., Pandey, G., Chalise, K., & Devkota, S. (2023). Clinicopathological profile of Papillary thyroid carcinoma in a tertiary cancer hospital in Nepal. Nepalese Journal of Cancer, 7(1), 108–115. https://doi.org/10.3126/njc.v7i1.60034

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Original Articles