Case Report of Suicide Attempt Using Zinc Phosphide in Nepal

Authors

  • Shirish Acharya Junior Consultant, Department of ICU, Karuna Hospital, Chunnikhel, Kathmandu, Nepal
  • Shubha Kalyan Shrestha Head, Department of ICU, Karuna Hospital, Chunnikhel, Kathmandu, Nepal
  • Rishav Sharma ICU registrar, Karuna Hospital, Chunnikhel, Kathmandu, Nepal
  • Bhanu Shrestha Medical officer, Department of ICU, Karuna Hospital, Chunnikhel, Kathmandu, Nepal
  • Parshu Ram Ghimire Consultant, Department of Internal Medicine, Karuna Hospital, Chunnikhel, Kathmandu, Nepal
  • Sameer Shrestha Medical officer, Department of ICU, Karuna Hospital, Chunnikhel, Kathmandu, Nepal
  • Samikshya Tamang Medical officer, Department of ICU, Karuna Hospital, Chunnikhel, Kathmandu, Nepal
  • Sabin Shrestha Medical officer, Department of ICU, Karuna Hospital, Chunnikhel, Kathmandu, Nepal

DOI:

https://doi.org/10.3126/bcja.v2i1.55762

Keywords:

Suicide, Zinc Phosphide, Intensive Care Monitoring

Abstract

Zinc phosphide is an easily available rodenticide and a common mode of poisoning in the Indian subcontinent. It is highly toxic with a mortality rate ranging from 37-100 percent. The proposed mechanism of toxicity is due to the release of phosphine gas after contact with gastric acid. The gas thus liberated, inhibits cytochrome C oxidase and oxidative respiration. The affected systems are cardiovascular, respiratory, gastrointestinal, hepatobiliary, and hematologic systems and cause electrolyte imbalance. Additionally, metabolic acidosis and an increase in lactate levels can be correlated with the degree of toxicity. The onset of effects can be as early as 4 hours and the risk gradually decrease after 72 hours. There is no antidote to the poison.

Aggressive intensive care monitoring and supportive management are the only methods. Early gastric lavage with activated charcoal to induce vomiting is advised. Attempts to clear the zinc phosphide early from the lumen with evidence in the X-ray abdomen using Castor oil have been tried, showing a beneficial effect. Along with this, antioxidants such as alpha-lipoic acid and injectable magnesium sulfate can prevent oxidative injury. Early use of Vitamin K and use of N-acetyl-cysteine have been used to prevent and treat liver injury. However, these methods have not been incorporated in the standard treatment regimen but have shown positive results in preventing mortality. Further extensive studies and standardized treatment is needed for Zinc phosphide poisoning.

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Published

2023-06-13

How to Cite

Acharya, S., Shrestha, S. K., Sharma, R., Shrestha, B., Ghimire, P. R., Shrestha, S., Tamang, S., & Shrestha, S. (2023). Case Report of Suicide Attempt Using Zinc Phosphide in Nepal. Baneshwor Campus Journal of Academia, 2(1), 74–81. https://doi.org/10.3126/bcja.v2i1.55762

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