Oxidative stress, plasma/salivary antioxidant status detection and health risk factors

Authors

  • Vadala Maria Researcher, Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena http://orcid.org/0000-0001-7873-5072
  • Palmieri Beniamino Professor, Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena http://orcid.org/0000-0002-0871-138X
  • Malagoli Andrea Researcher, Department of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena http://orcid.org/0000-0001-7857-4133
  • Laurino Carmen Researcher, Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena, Italy. Network of the Second Opinion, Modena (MO) http://orcid.org/0000-0002-3020-2338

DOI:

https://doi.org/10.3126/ajms.v8i1.15134

Keywords:

Antioxidant, Factor, Oxidative, Plasma, Stress, Risk, Test, Saliva

Abstract

Background: Oxidative stress is involved in the pathophysiology of several diseases such as cardiovascular disorders, cancer, neurodegeneration.

Aims and Objectives: Our study evaluated the oxidant/antioxidant status on a cohort of healthy patients matched with some independent variables as a basic individual redox balance monitor on a disease-prevention perspective.

Materials and Methods: The anecdotic, retrospective and observational study included 200 apparently healthy volunteers after formal informed consent release whose personal history and physical examination had been recorded specifically on the following items: age, previous diseases, sport activities, smoking habit, balanced/unbalanced nutrition, current absence/presence of inflammatory processes, oral health hygiene, administration of oral contraceptives or hormone replacement therapy in postmenopausal women. No drug treatment was admitted in the recruited patients, up to 6 months before the evaluation. The laboratory instruments used were Point of care FRAS 4 Evolvo (H&D, Parma, Italy) measuring the oxidative stress in plasma samples and antioxidant capacity in plasma and saliva samples.

Results: Two-hundred patients were recruited. Statistically relevant differences were observed in oxidative stress-related variables, namely a significant relationship between plasma oxidative stress level and female gender (p<0.01), between saliva antioxidant level and age (p=0.01), between plasma antioxidant level and unbalanced diet (p<0.01), between plasma oxidative stress level and inflammation in the oral cavity (p=0.04), and between saliva antioxidant level and inflammation in the oral cavity (p<0.01).

Conclusions: A relationship between oxidative/antioxidant status and health risk factors has been outlined in our study; the achieved data are quite helpful, in the clinical practice, providing additional information on individual general health conditions, putatively related to prevention diagnosis, prognosis, and treatment effectiveness in some specific diseases.

Asian Journal of Medical Sciences Vol.8(1) 2017 32-41

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Author Biography

Vadala Maria, Researcher, Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena


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Published

2017-01-03

How to Cite

Maria, V., Beniamino, P., Andrea, M., & Carmen, L. (2017). Oxidative stress, plasma/salivary antioxidant status detection and health risk factors. Asian Journal of Medical Sciences, 8(1), 32–41. https://doi.org/10.3126/ajms.v8i1.15134

Issue

Vol. 8 No. 1 (2017)

Section

Original Articles

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