Central Pontine Demyelination: A Case Report

Authors

  • Manju Maharjan Annapurna Neurological Institute and Allied Sciences Maitighar, Kathmandu
  • Pranaya Shrestha Annapurna Neurological Institute and Allied Sciences Maitighar, Kathmandu
  • Avinash Chandra Annapurna Neurological Institute and Allied Sciences Maitighar, Kathmandu
  • Jemesh S Maharjan Annapurna Neurological Institute and Allied Sciences Maitighar, Kathmandu
  • Basant Pant Annapurna Neurological Institute and Allied Sciences Maitighar, Kathmandu

DOI:

https://doi.org/10.3126/njn.v13i2.20487

Keywords:

Central pontine demyelination, Cerebral edema, Hyponatremia, Pons

Abstract

Central Pontine Demyelination is a neurological disease caused by rapidly fl uctuating serum osmolality resulting in severe damage of the myelin sheath of nerve cells in the brainstem, more precisely in the area of pons. This condition is associated with electrolyte disorders, especially severe hyponatremia and its rapid correction. Its clinical course is characterized by alterations in the mental status to debilitating neurological status i.e. coma. Chronic hyponatremia and its correction, with or without evaluating safe limit could result in pontine demyelination. Demyelination might also occur with normal sodium levels, and even if serum sodium levels are corrected within safe limits. The objective of this case report is to give a broad perspective on Central Pontine Demyelination and to discuss about the different factors contributing to the demyelination and the various causes, pathophysiology and the management of this condition.

 Nepal Journal of Neuroscience. Vol. 13, No. 2, 2016, Page: 99-101

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Published

2016-12-01

How to Cite

1.
Maharjan M, Shrestha P, Chandra A, Maharjan JS, Pant B. Central Pontine Demyelination: A Case Report. Nep J Neurosci [Internet]. 2016 Dec. 1 [cited 2024 Nov. 13];13(2):99-101. Available from: https://nepjol.info/index.php/NJN/article/view/20487

Issue

Section

Case Report