Gonococcal infections: The trends of antimicrobial susceptibility of Neisseria gonorrhoeae in Western Nepal

Authors

  • DR Bhatta Department of Microbiology, Manipal College of Medical Sciences, Pokhara
  • S Gokhale Department of Microbiology, Manipal College of Medical Sciences, Pokhara
  • MT Ansari Department of Microbiology, Manipal College of Medical Sciences, Pokhara
  • HK Tiwari Department of Microbiology, Manipal College of Medical Sciences, Pokhara
  • A Gaur Department of Microbiology, Manipal College of Medical Sciences, Pokhara
  • JP Mathuria Department of Microbiology, Manipal College of Medical Sciences, Pokhara
  • AN Ghosh Department of Microbiology, Manipal College of Medical Sciences, Pokhara

DOI:

https://doi.org/10.3126/njms.v1i2.6603

Keywords:

Antimicrobial susceptibility, gonorrhoeae, N. gonorrhoeae, urethritis

Abstract

Background: Gonorrhea is caused by Neisseria gonorrhoeae, is an important public health problem and is the second most common reportable sexually transmitted bacterial infection. Present study was conducted to determine the antimicrobial resistance pattern of Neisseria gonorrhoeae isolates from various clinical specimens.

Methods: This is a hospital based retrospective study conducted at Manipal Teaching Hospital, Pokhara, Nepal. Various clinical specimens (urethral, cervical and conjunctival discharges) were collected from the suspected cases of gonococcal infections between January 2004 to December 2010. Specimens were subjected to Gram stain and culture on chocolate agar. Antibiotic susceptibility testing was performed on chocolate agar by Kirby Bauer’s disc diffusion method.

Results: A total of 119 patients were tested for gonococcal infections. Forty-eight patients were diagnosed as having gonococcal infections, of which 40 cases were culture positive. Penicillin resistance was seen in 27 (67%) cases while all isolates were sensitive to ceftriaxone.

Conclusion: Neisseria gonorrhoeae isolates are becoming increasingly resistant to antibiotics like penicillin, ciprofloxacin and tetracycline. Therefore, continuous surveillance of antibiotic resistance pattern is required in order to start empirical antibiotic therapy in high risk population like commercial sex workers.

DOI: http://dx.doi.org/10.3126/njms.v1i2.6603

Nepal Journal of Medical Sciences. 2012;1(2): 74-78

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Published

2012-08-02

How to Cite

Bhatta, D., Gokhale, S., Ansari, M., Tiwari, H., Gaur, A., Mathuria, J., & Ghosh, A. (2012). Gonococcal infections: The trends of antimicrobial susceptibility of Neisseria gonorrhoeae in Western Nepal. Nepal Journal of Medical Sciences, 1(2), 74–78. https://doi.org/10.3126/njms.v1i2.6603

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Section

Original Articles