Noninvasive diagnosis of Helicobacter pylori among patients with dyspepsia

Authors

  • Suresh Thapa Pokhara Academy of Health Sciences, Western Regional Hospital, Nepal.
  • Jiwan Thapa National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal
  • Binod Karki National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal
  • Dibas Khadka National Academy of Medical Sciences, Bir Hospital
  • Anju Bhandari Thapa National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal

DOI:

https://doi.org/10.3126/njms.v5i1.36944

Keywords:

Dyspepsia, Gastritis, Helicobacter pylori, Noninvasive tests

Abstract

Introduction: Helicobacter pylori (H. pylori) infection is a common disease with disparity in geography, age, race and socioeconomic status. Present study aims to assess the accuracy of noninvasive diagnostic tests.

Methods: This is a hospital based cross sectional, observational study of 100 dyspeptic patients during November 2017- June 2018. Profile of dyspeptic patients were recorded in a proforma and accuracy of serology and stool antigen test for H. pylori was compared with histology detection in gastric biopsies.

Results: Mean age of patients was 39.5±13.7 years with almost equal gender distribution. Prevalence of H. pylori was 56% with dyspeptic symptoms in gastric biopsies. Significant association of the infection was seen in patients with a longer duration of dyspepsia, pangastritis on endoscopy and chronic gastritis on histologic examination. Stool antigen test had good sensitivity (71%) and specificity (82%) for H. pylori detection compared with standard histological diagnosis.

Conclusion: Overall prevalence of H. pylori was 56% and was more common in patients of age > 44 years with dyspepsia. Stool antigen has a good diagnostic accuracy and can be used in resource limited settings. However, we recommend a community based study in larger population.

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Author Biographies

Suresh Thapa, Pokhara Academy of Health Sciences, Western Regional Hospital, Nepal.

Department of Internal Medicine 

Jiwan Thapa, National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal

Department of Medicine, Gastroenterology Unit

Binod Karki, National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal

Department of Medicine, Gastroenterology Unit

Dibas Khadka, National Academy of Medical Sciences, Bir Hospital

Department of Medicine, Gastroenterology Unit 

Anju Bhandari Thapa, National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal

Department of Pathology

 

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Published

2020-02-15

How to Cite

Thapa, S., Thapa, J., Karki, B., Khadka, D., & Bhandari Thapa, A. (2020). Noninvasive diagnosis of Helicobacter pylori among patients with dyspepsia. Nepal Journal of Medical Sciences, 5(1), 28–34. https://doi.org/10.3126/njms.v5i1.36944

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Section

Original Articles