Comparative Study of Efficacy and Safety of Diacerein versus Acelofenac in Patient with Knee Osteoarthritis

Authors

  • Sashmit Sharma Kathmandu Medical College, Kathmandu, Nepal
  • Kiran Prasad Rijal Kathmandu Medical College, Kathmandu, Nepal
  • Tanup Prasai Kathmandu Medical College, Kathmandu, Nepal
  • Himal Khanal Kathmandu Medical College, Kathmandu, Nepal

DOI:

https://doi.org/10.3126/njms.v6i1.36729

Keywords:

Diacerein, Osteoarthritis Knee, Nepalese, Aceclofenac

Abstract

Introduction: There are different pharmacological modalities currently in practice for the treatment of osteoarthritis knee. Broadly these are divided into anti-inflammatory drugs such as NSAIDs and symptomatic slow-acting drugs in osteoarthritis (SYSADOA). Diacerein, an anthraquinone derivative inhibits IL-1b and has been shown to significantly decrease the symptoms.
Methods: This is open label, prospective comparative study. Total 40 patients were divided into two groups: group A (diacerein) and group B (aceclofenac) by alternate method. In group A diacerein was given 50mg orally for 1 week followed by 50 mg orally twice a day for 3 weeks. In group B aceclofenac 200 mg sustained release tablet was given orally once a day for 4 weeks. Outcomes were measured at the end of the treatment period i.e. at four weeks and after two weeks of discontinuation of treatment i.e. at 6 weeks.
Results: Improvement is observed in both treatment groups in their baseline value in terms of efficacy parameters. Results of VAS and WOMAC scores were better in group B (aceclofenac). However intra-group analysis showed VAS scores and WOMAC scores significantly decreased in patients receiving diacerein as well. (p<0.05).
Conclusion: Though not superior to the control drug, diacerein showed efficacy in terms of measurement by patient self-reported WOMAC and VAS scores for the treatment of Osteoarthritis knee.

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Author Biographies

Sashmit Sharma, Kathmandu Medical College, Kathmandu, Nepal

Assistant Professor

Department of Orthopaedics

Kiran Prasad Rijal, Kathmandu Medical College, Kathmandu, Nepal

Professor

Department of Orthopaedics

Tanup Prasai, Kathmandu Medical College, Kathmandu, Nepal

Department of Orthopaedics

Himal Khanal, Kathmandu Medical College, Kathmandu, Nepal

Department of Orthopaedics

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Published

2021-04-30

How to Cite

Sharma, S., Rijal, K. P., Prasai, T., & Khanal, H. (2021). Comparative Study of Efficacy and Safety of Diacerein versus Acelofenac in Patient with Knee Osteoarthritis. Nepal Journal of Medical Sciences, 6(1), 26–33. https://doi.org/10.3126/njms.v6i1.36729

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Section

Original Articles