Isoniazid - induced chronic cutaneous Lupus erythematosus

Authors

  • A Chiriac Nicolina Medical Center, Iasi, Romania
  • P Brzezinski Military Support Unit, Ustka
  • A E Chiriac Department of Dermatology University of Medicine and Pharmacy "Gr. T. Popa" Iasi
  • L Foia University of Medicine and Pharmacy "Gr. T. Popa" Iasi
  • D Mihaila Department of Dermatology, University of Medicine and Pharmacy "Gr. T. Popa" Iasi
  • C Solovan Department of Dermatology, University of Medicine V Babes, Timisoara

Keywords:

Drug-induced chronic cutaneous lupus erythematosus, Isoniazid, Tuberculosis

Abstract

A 23-year-old man developed drug-induced chronic cutaneous lupus erythematosus 8 months after isoniazid (INH) therapy for pulmonary tuberculosis. Diagnosis was based on clinical aspects (discoid lesions on the face, erythema, photosensitivity, hyperpigmentation), histopathological examination, along with direct immunofluorescence examination (DIF), the absence of systemic involvement and the routine laboratory parameters, which registered all within normal range. Hydroxychloroquine therapy associated to photo protection and emollients determined the clear up of the facial eruption within six months. Transient residual hyperpigmentation could be noticed 2 months after discontinuation of the treatment. This case illustrates a rare form of drug-induced chronic cutaneous lupus erythematosus developed 2 months after withdrawal of antituberculosis therapy, with excellent results with hydroxychloroquine.

NJDVL Vol. 13, No. 1, 2015 Page: 52-56

Abstract
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Author Biographies

A Chiriac, Nicolina Medical Center, Iasi, Romania

Head of Department of Dermatology

P Brzezinski, Military Support Unit, Ustka

Head of Department of Dermatology

A E Chiriac, Department of Dermatology University of Medicine and Pharmacy "Gr. T. Popa" Iasi

Student

L Foia, University of Medicine and Pharmacy "Gr. T. Popa" Iasi

Head, Head of Department of Dermatology

C Solovan, Department of Dermatology, University of Medicine V Babes, Timisoara

Head of Department of Dermatology

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Published

2016-01-12

Issue

Vol. 13 No. 1 (2015)

Section

Case Reports

License

This license enables re-users to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.

How to Cite

Chiriac, A., Brzezinski, P., Chiriac, A. E., Foia, L., Mihaila, D., & Solovan, C. (2016). Isoniazid - induced chronic cutaneous Lupus erythematosus. Nepal Journal of Dermatology, Venereology & Leprology, 13(1), 52-56. https://doi.org/10.3126/njdvl.v13i1.14306