Recent advances in the use of Glycoprotein (GP) Ilb/Illa receptors inhibitors

Authors

  • Roshan Raut
  • Man Bahadur KC
  • Deewakar Sharma
  • Sujeeb Rajbhandari
  • Sajan G Baidhya

DOI:

https://doi.org/10.3126/njh.v4i1.26157

Keywords:

glycoprotein receptors inhibitors

Abstract

Glycoprotein IIb/IIIa receptors are the most common receptor subtypes on the platelet surface. During vessel injury, the sub-endothelial layer is exposed so that platelets adhere to sub-endothelial collagen via la/Ila receptor and to von Willebrand factor via glycoprotein Ib receptor. Adherent platelets are activated by ADP, 5-HT, TXA2 etc which result in the conformational change of platelets, thereby activating nearly 80,000 GP IIb/IIIa receptors on platelet surface. These activated receptors bind fibrinogen to fascilate the formation of a platelet plug.1,2

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Published

2006-11-30

How to Cite

Raut, R., KC, M. B., Sharma, D., Rajbhandari, S., & Baidhya, S. G. (2006). Recent advances in the use of Glycoprotein (GP) Ilb/Illa receptors inhibitors. Nepalese Heart Journal, 4(1), 112–124. https://doi.org/10.3126/njh.v4i1.26157

Issue

Vol. 4 No. 1 (2006)

Section

Review Articles

License

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