Bevacizumab in Retinopathy of Prematurity : Concerns and adverse effects

Authors

  • Anuj Sharma Neoretina Eyecare Institute, Hyderabad, Telangana, India http://orcid.org/0000-0002-8240-0539
  • Adheesh Shetty Aravind Eye Hospital, Tirunelveli, Tamil Nadu, India
  • Y.C. Venu Gopal Reddy Aravind Eye Hospital, Tirunelveli, Tamil Nadu, India

DOI:

https://doi.org/10.3126/nepjoph.v12i2.28993

Keywords:

Bevacizumab, Retinopathy of Prematurity, BEAT-ROP, Neuro-developmental delay

Abstract

Retinopathy of prematurity (ROP) ranks as one of the leading causes of blindness in the paediatric age group, the incidence of which is increasing in developing countries as the economy strengthens and healthcare practices improve. As a vasoproliferative disorder affecting premature neonates VEGF is said to play a vital role in the pathogenesis of ROP. Evidence of the efficacy of anti-VEGF agents in treatment of ROP have been seen in literature since early 2007 with most published reports being either case studies or small case series. The only randomised controlled trial in this regard was the BEAT-ROP study which was published in 2011. However, even in that study the adverse effects of Bevacizumab were not analysed. This review aims to discuss the complications prior to the blanket administration of intravitreal bevacizumab in the management of ROP.

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Published

2020-10-05

How to Cite

Sharma, A., Shetty, A., & Reddy, Y. V. G. (2020). Bevacizumab in Retinopathy of Prematurity : Concerns and adverse effects. Nepalese Journal of Ophthalmology, 12(2), 298–307. https://doi.org/10.3126/nepjoph.v12i2.28993

Issue

Section

Review Article