Efficacy of Itraconazole Versus Terbinafine for the Treatment of Tineacruris.

Abstract

Introduction: Tenia Cruris is the commonest dermatophyte infection which is common in men and aggravated by warm humid condition Teniarubrum is the main species for the disease^{1, 2}. Itraconazole and Terbinafine are the better newer drugs for the therapeutic option due to their efficacy, convenient and less side effect. Itraconazole is a wider spectrum Thiazole group of fungistatic drugs which inhibit sterol 14 ? demethylase impairing biosynthesis of fungal ergosterol. Similarly Terbinafine is broad specturmallylamine group of fungicidal activity which inhibits squalene 2, 3 epoxidase enzyme thus inhibit fungal biosynsthesis of ergosterol^3-5. These two drugs have been needed conventionally as a pulse and continuous therapy. The main aim of this study is to compare the efficacy of both drugs and to recommend the eff ective treatment in case of Teniacruris.

Methods: In this randomized comparative study, the efficacy and safety of oral itraconazole (n=35) and terbinafine (n=35), each given for 2weeks, was compared in patients with tineacruris within the period of 1 year study.

Results: The final evaluation at week 4 showed a cure rate of 91.4% for itraconazole and 82.9% for terbinafine. No definite adverse effect was noted.

Conclusions: Itraconazolehas high cure rate and less failure rate without side effects in comparision to Terbinafine.

Medical Journal of Shree Birendra Hospital; Jan-June 2012/vol.11/Issue1/24-26

DOI: http://dx.doi.org/10.3126/mjsbh.v11i1.7763