Effect of Chemical Enhancers on In Vitro Release of Salbutamol Sulphate from Transdermal Patches

Authors

  • Uttam Budhathoki Department of Pharmacy Kathmandu University, Dhulikhel, Kavre, P.O. Box: 6250, Kathmandu, Nepal
  • Panna Thapa Department of Pharmacy Kathmandu University, Dhulikhel, Kavre, P.O. Box: 6250, Kathmandu, Nepal

DOI:

https://doi.org/10.3126/kuset.v1i1.64250

Abstract

The effect of combination of PG with DMSO, BC, IPM, Tween 80 and SLS on drug release rate was studied in vitro. The mechanism of drug release was also studied by using power law. Significant difference (One way ANOVA; p<0.05) in release rate among the 16 formulations was seen in the study. The release profiles of various formulations also showed that the added enhancers in individual batches affect the release rate of the drug. The concentration of DMSO and Tween 80 showed directly proportional where as concentration of BC and SLS showed inversely proportional relationship with drug release rate. The increase followed by decrease in drug release rate was seen with increase in IPM concentration. In most of the formulations, drug release occurred by diffusion partially through a swollen matrix and water-filled pores.

Downloads

Download data is not yet available.
Abstract
34
PDF
20

Downloads

Published

2005-09-30

How to Cite

Budhathoki, U., & Thapa, P. (2005). Effect of Chemical Enhancers on In Vitro Release of Salbutamol Sulphate from Transdermal Patches. Kathmandu University Journal of Science, Engineering and Technology, 1(1). https://doi.org/10.3126/kuset.v1i1.64250

Issue

Vol. 1 No. 1 (2005)

Section

Original Research Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. If you remix, adapt, or build upon the material, you must license the modified material under identical terms.