Association of Non High Density Lipoprotein-Cholesterol and HbA1c in Type 2 Diabetes Mellitus

Authors

  • Saroj Thapa Department of Clinical Biochemistry, Kathmandu University School of Medical Sciences, Dhulikhel, Nepal https://orcid.org/0000-0003-1234-644X
  • Nirish Vaidya Department of Internal Medicine, Kathmandu University School of Medical Sciences, Dhulikhel, Nepal
  • Rachana Pandey Department of Clinical Biochemistry, Kathmandu University School of Medical Sciences, Dhulikhel, Nepal
  • Jyoti Shrestha Takanche Department of Clinical Biochemistry, Kathmandu University School of Medical Sciences, Dhulikhel, Nepal

DOI:

https://doi.org/10.3126/jonmc.v12i2.61111

Keywords:

Dyslipidemia, Glycated hemoglobin, Type 2 diabetes

Abstract

Background: Dyslipidemia is a common issue among diabetic patients and is associated with an increased risk of cardiovascular disease. Non-High Density Lipoprotein-cholesterol has emerged as a valuable marker for assessing combined cardiovascular risk in diabetes. Measures to improve the Non-High Density Lipoprotein-cholesterol within optimal level might improve the glycemic status and decrease the cardiovascular risk. This study aims to examine the relationship between Non-High Density Lipoprotein-cholesterol and glycated hemoglobin levels in type 2 diabetic patients.

Materials and Methods: A hospital-based comparative cross-sectional study was conducted on 544 individuals diagnosed with type 2 diabetes. The classification of lipid profile and glycemic control was carried out as per the National Cholesterol Education Program Adult Treatment Plan III and American Diabetes Association guidelines.

Results: Our study found that Non-High Density Lipoprotein-cholesterol levels was higher in uncontrolled diabetes (157.9±46.8) compared to controlled diabetes (132.6±40.6), with a statistically significant difference (P<0.001). There was a weak positive correlation between Non-High Density Lipoprotein-cholesterol and glycated hemoglobin levels (r=0.37).Among the total participants, 226 (41.5%) had optimal Non-High Density Lipoprotein-cholesterol level whereas 318 (58.5%) had high Non-High Density Lipoprotein-cholesterol.

Conclusion: This study confirms a positive correlation between Non-High Density Lipoprotein-cholesterol and HbA1c levels in type 2 diabetic patients. Dyslipidemia prevalence was substantial, emphasizing the importance of achieving target Non-High Density Lipoprotein-cholesterol levels for improved glycemic control and cardiovascular risk reduction.

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Author Biography

Saroj Thapa, Department of Clinical Biochemistry, Kathmandu University School of Medical Sciences, Dhulikhel, Nepal

Assistant Professor

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Published

2023-12-31

How to Cite

Thapa, S., Vaidya, N., Pandey, R., & Takanche, J. S. (2023). Association of Non High Density Lipoprotein-Cholesterol and HbA1c in Type 2 Diabetes Mellitus. Journal of Nobel Medical College, 12(2), 30–35. https://doi.org/10.3126/jonmc.v12i2.61111

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Original Articles