Incidence and Risk Factors Associated with Blood Culture Proven Neonatal Sepsis

Authors

  • Nikita Singh Yadav Universal College of Medical Sciences, Bhairahawa, Nepal
  • Pranav Kumar Yadav Universal College of Medical Sciences, Bhairahawa, Nepal
  • Rajeshwar Reddy Kasarla Universal College of Medical Sciences, Bhairahawa, Nepal
  • Pramila Parajuli St. Xavier’s College, Maitighar, Kathmandu

DOI:

https://doi.org/10.3126/jucms.v9i01.37963

Keywords:

Blood culture, Neonatal Sepsis, Risk factors

Abstract

INTRODUCTION

Neonatal sepsis (sepsis neonatorum) is a clinical syndrome resulting from the pathophysiologic effects of local or systemic infection. This is a major cause of morbidity and mortality around the world affecting newborns up to one month of age with clinical symptoms and positive blood cultures.  This study aimed at examining the risk factors of neonatal sepsis at pediatric tertiary care hospital.

 

MATERIAL AND METHODS

This was a hospital based cross-sectional case control study conducted among 350 neonates admitted within April to September 2015 at the Kanti Children’s Hospital, Kathmandu Nepal. Cases were neonates who had sepsis and controls were neonates who did not have sepsis with their index mothers.  CRP screening tests and blood culture was performed. Data were entered using the SPSS (Version 22).  Bivariate and multivariate logistic regression was used to determine the risk of neonatal sepsis.

 

RESULTS

A total of 59 (17%) neonates who had sepsis (cases) with their index mothers’ and 291 (83%) neonates who had no sepsis (controls) with their index mothers were enrolled. Maternal factors that predicted the occurrence of sepsis among neonates were parity (p<0.027), mode of delivery (p<0.001) and PROM (p<0.001). Neonatal risk factors which predicted the occurrence of sepsis were duration of stay in the facility (p<0.001) and neonatal age on admission (p<0.001).

 

CONCLUSION

The study found both maternal and neonatal factors to have a strong association with the risk of developing neonatal sepsis. Encouraging maternal antenatal care utilization would help identify the risk factors during prenatal and postnatal care and appropriate interventions implemented to reduce the likelihood of the neonate developing sepsis.

 

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Author Biographies

Nikita Singh Yadav, Universal College of Medical Sciences, Bhairahawa, Nepal

Department of Microbiology

Pranav Kumar Yadav, Universal College of Medical Sciences, Bhairahawa, Nepal

Department of Anatomy

Rajeshwar Reddy Kasarla, Universal College of Medical Sciences, Bhairahawa, Nepal

Department of Microbiology

Pramila Parajuli, St. Xavier’s College, Maitighar, Kathmandu

Department of Microbiology

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Published

2021-06-22

How to Cite

Yadav, N. S., Yadav, P. K., Kasarla, R. R., & Parajuli, P. (2021). Incidence and Risk Factors Associated with Blood Culture Proven Neonatal Sepsis. Journal of Universal College of Medical Sciences, 9(01), 28–32. https://doi.org/10.3126/jucms.v9i01.37963

Issue

Section

Original Articles