New Remedies from Natural Products in Brain Stroke

Authors

  • Haushila Prasad Pandey Department of Biochemistry, Universal College of Medical Sciences & Teaching Hospital, Bhairahawa
  • Vaibhav Mishra Department of Environmental Microbiology, Babasaheb Bhimrao Ambedkar University, Lucknow
  • Dr. Akanksha Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow

DOI:

https://doi.org/10.3126/jucms.v4i2.19090

Keywords:

Apoptosis, Ischemia, Stroke, Brain, Neuro-inflammation

Abstract

 Acute ischemic stroke is the third leading cause of death and the most frequent cause of permanent disability. Despite advances in the understanding of the pathophysiology of cerebral ischemia, therapeutic options remain limited. Only recombinant tissue-plasminogen activator (rt-PA) for thrombolysis is currently approved for use in the treatment of stroke. However, its use is limited by its short therapeutic window (three hours), complications derived essentially from the risk of haemorrhage, and the potential damage from reperfusion/ischemic injury. Two important pathophysiological mechanisms involved during ischemic stroke are oxidative stress and inflammation3. On the basis of pre existing literatures, brain tissue is not well equipped with antioxidant defenses. So for a future candidate drug that may able to cure the stroke it must have anti oxidant and anti inflammatory properties. This review will discuss the molecular and biochemical aspects of oxidative stress and inflammation in ischemic stroke that targets neuro-inflammation through natural products.

Journal of Universal College of Medical Sciences (2016)

Vol.04 No.02 Issue 14, page: 35-39

Downloads

Download data is not yet available.
Abstract
496
PDF
508

Author Biography

Haushila Prasad Pandey, Department of Biochemistry, Universal College of Medical Sciences & Teaching Hospital, Bhairahawa

Professor and Head

Downloads

Published

2018-01-25

How to Cite

Pandey, H. P., Mishra, V., & Akanksha, D. (2018). New Remedies from Natural Products in Brain Stroke. Journal of Universal College of Medical Sciences, 4(2), 35–39. https://doi.org/10.3126/jucms.v4i2.19090

Issue

Vol. 4 No. 2 (2016)

Section

Review Articles

License

Authors have to give the following undertakings along with their article:

  1. I/we declare that this article is original and has not been submitted to another journal for publication.
  2. I/we declare that I/we surrender all the rights to the editor of the journal and if published will be the property of the journal and we will not publish it anywhere else, in full or part, without the permission of the Chief Editor.
  3. Institutional ethical and research committee clearance certificate from the institution where work/research was done, is required to be submitted.
  4. Articles in the Journal are Open Access articles published under the Creative Commons CC BY-NC License (https://creativecommons.org/licenses/by-nc/4.0/)
  5. This license permits use, distribution and reproduction in any medium, provided the original work is properly cited, and it is not used for commercial purposes.