Histomorphological patterns of skin adnexal tumours with an insight into molecular updates - A single institutional study

Authors

  • Sangeetha Kandasamy St Peter’s Medical College Hospital and Research Institute, Tamil Nadu, India
  • Roopmala Murugan Sri Ramachandra Medical College and Research Institute, Chennai, India
  • Gramani Arumugam Vasugi Sri Ramachandra Medical College and Research Institute, Chennai, India
  • Kumudhini Priya Gunasekaran Vinayaka Mission’s Kirupananda Variyar medical college and Hospitals, Salem, India https://orcid.org/0009-0008-8206-9445

DOI:

https://doi.org/10.3126/jpn.v13i1.43167

Keywords:

Skin adnexal tumors, histopathology, molecular updates, categorization

Abstract

Background: Skin adnexal tumors are a spectrum of benign and malignant tumors that differentiate toward or arise from the adnexal unit of the skin. These rare tumors pose a challenge in diagnosis, and often, a discrepancy is seen between clinical and histopathological diagnosis.

Materials and methods: This single institutional study was carried out among 36 patients who presented with swelling. An initial diagnosis was considered based on the clinical history followed by histopathological examination.

Results: Among the 36 patients, only 4 had malignant tumors. Among them, 3 had sebaceous differentiation, and 1 had apocrine and eccrine differentiation. Among the benign, 14 had follicular differentiation, 12 had apocrine and eccrine differentiation, and 6 had sebaceous differentiation. The clinic-pathological correlation was 65%.

Conclusions: An accurate diagnosis is not possible with just the clinical features. Histopathologic examination is considered the gold standard for diagnosis and categorization.

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Author Biographies

Sangeetha Kandasamy, St Peter’s Medical College Hospital and Research Institute, Tamil Nadu, India

Assistant Professor, Department of Pathology

Roopmala Murugan, Sri Ramachandra Medical College and Research Institute, Chennai, India

Department of Pathology

Gramani Arumugam Vasugi , Sri Ramachandra Medical College and Research Institute, Chennai, India

Department of Pathology

Kumudhini Priya Gunasekaran, Vinayaka Mission’s Kirupananda Variyar medical college and Hospitals, Salem, India

Department of Pathology

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Published

2023-07-12

How to Cite

Kandasamy, S., Murugan, R., Vasugi , G. A., & Gunasekaran, K. P. (2023). Histomorphological patterns of skin adnexal tumours with an insight into molecular updates - A single institutional study. Journal of Pathology of Nepal, 13(1), 2008–2012. https://doi.org/10.3126/jpn.v13i1.43167

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Original Articles