Esthesioneuroblastoma: an institutional based descriptive study of a rare tumor

Authors

DOI:

https://doi.org/10.3126/jpn.v13i1.42524

Keywords:

Esthesioneuroblatoma, Flexner-Wintersteiner, Homer Wright pseudorosettes, Olfactory neuroblastoma, Pseudorosette, Rosette, Sinonasal tract

Abstract

Background: Esthesioneuroblastoma is a slow-growing rare malignant neuroectodermal tumor arising from the olfactory epithelium. It has a bimodal incidence with peaks in the second and third decades of life and the sixth and seventh decades of life with equal incidence among men and women. Prognostic factors include the Hyams grade and modified Kadish stage. This study analyzed the clinicopathological features of esthesioneuroblastoma.

Materials and methods- Retrospective study of patients who were diagnosed with esthesioneuroblastoma at a tertiary care hospital between January 2012 and May 2019 was conducted.  The research was performed according to the World Medical Association Declaration of Helsinki. Institutional research committee approval (IEC: 473/2019) was obtained.

Results: Clinicopathological profiles of 8 patients who were diagnosed with esthesioneuroblastoma during the period were included. Among the eight patients, five were female and three were male.  Common presenting complaints were nasal obstruction, difficulty in breathing, epistaxis, local pain, and anosmia. The average age of presentation was 52 years, ranging from 14 to 73 years. Anterior rhinoscopic examination in these cases showed a polypoid mass located in the nasal cavity. According to the Hyams grading system, three of the eight cases were grade-2 and the remaining five cases were grade-3 Hyams histological grade. Three cases exhibited foci of ganglioneuroblastic transformation. Three patients had metastases to cervical lymph nodes and three patients had recurrence.

Conclusions: Esthesioneuroblastoma is a rare aggressive malignant tumor. It can exhibit divergent epithelial or ganglionic differentiation. A proper diagnosis should be made, graded and staged before proceeding to treatment.

Downloads

Download data is not yet available.
Abstract
75
PDF
105

Author Biographies

Geetha Vasudevan, Kasturba medical college, Manipal Academy of Higher Education, Manipal, India

Additional professor, Department of Pathology

Srilatha Parampalli Srinivas, Manipal Academy of Higher Education, Manipal, India

Associate professor, Department of Pathology

Padmapriya Jaiprakash, Kasturba medical college, Manipal Academy of Higher Education, Manipal, India

Associate professor, Department of Pathology

Kailesh Pujary, Kasturba medical college, Manipal Academy of Higher Education, Manipal, India

Professor, Department of Otorhinolaryngology

Downloads

Published

2023-05-28 — Updated on 2023-07-12

How to Cite

Vasudevan, G., Parampalli Srinivas, S., Jaiprakash, P., & Pujary, K. (2023). Esthesioneuroblastoma: an institutional based descriptive study of a rare tumor. Journal of Pathology of Nepal, 13(1), 1970–1975. https://doi.org/10.3126/jpn.v13i1.42524

Issue

Section

Original Articles