Dedifferentiated chordoma, a case report

Authors

DOI:

https://doi.org/10.3126/jpn.v12i1.42213

Keywords:

Chordoma; Dedifferentiation; Immunohistochemistry; Sarcoma

Abstract

Dedifferentiated chordoma is a rare variant of chordoma, exhibiting simultaneous presence of  conventional chordoma and component of high grade sarcoma. It occurs either de novo or in the form of high grade transformation of a conventional chordoma in a setting of recurrence or radiotherapy induced changes. Despite similar clinical manifestations, it shows significantly poorer survival among all variants of chordomas, making an accurate diagnosis important. We, herein, report a case of large chordoma in a 65 years old female, arising de novo in sacrum, where dedifferentiated component was present only focally, highlighting the importance of adequate grossing.

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Author Biographies

Girishma Shrestha, Patan Academy of Health Sciences, Lagankhel, Nepal

Department of Pathology

Paromita Roy, Tata Medical Center, India

Department of pathology

Indu Arun, Tata Medical Center, India

Department of pathology

Argha Chatterjee, Tata Medical Center, India

Department of Radiology

Gautam Biswas, Tata Medical Center, India

Department of surgery

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Published

2022-03-31

How to Cite

Shrestha, G., Roy, P., Arun, I., Chatterjee, A., & Biswas, G. (2022). Dedifferentiated chordoma, a case report. Journal of Pathology of Nepal, 12(1), 1946–1949. https://doi.org/10.3126/jpn.v12i1.42213

Issue

Vol. 12 No. 1 (2022)

Section

Case Reports

License

Copyright (c) 2022 Girishma Shrestha, Paromita Roy, Indu Arun, Argha Chatterjee, Gautam Biswas

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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