Clinical profile and outcome of COVID-19 in pediatric hematology-oncology patients

Authors

DOI:

https://doi.org/10.3126/jpahs.v8i3.30423

Keywords:

Cancer, Children, COVID-19

Abstract

Introduction: Pediatric hematology-oncology patients are assumed to be predisposed to severe COVID-19 disease and complications, but robust data from low- and middle-income countries is lacking. This study was designed with the primary objective of finding the prevalence and outcome of COVID- 19 in children with hematological or oncological diseases. Clinical characteristics of COVID-19, outcomes in terms of need for respiratory support, intensive care, mechanical ventilation or mortality, delay in therapy, and use of COVID-19 directed therapy were analyzed.

Method: Retrospective review of all children with hematological or oncological diseases with confirmed COVID-19 managed at Patan Hospital from Jan 2020 to Sep 2021. Patients were screened according to the hospital screening protocol. The clinical characteristics and outcomes of COVID-19 along with the delay in chemotherapy or local therapy were recorded.

Result: Twelve children tested positive for SARS- CoV-2 during the study period, and one had reinfection with COVID-19, 9(75%) were oncology patients, while 3(25%) were hematology patients. Fever (83.3%) was the most common symptom, followed by cough (58.3%). Four (33.3%) children had mild infections, and 4(33.3%) had severe infections. Eight oncology patients had delays in starting or continuing chemotherapy or undergoing surgery due to COVID-19. The median duration of delay was 10.5 d (range-7-21 d). The delay in therapy in patients with COVID-19 was significant in comparison to children without COVID-19.

Conclusion: The majority of pediatric hematology-oncology patients recovered from COVID-19 without sequelae. There was a delay in providing treatment to oncology patients due to changing protocols.

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Author Biographies

Sucharita Tuladhar, Patan Academy of Health Sciences, Lalitpur, Kathmandu, Nepal

Lecturer, Department of Paediatrics, Patan Hospital

Puja Amatya, Patan Academy of Health Sciences, Lalitpur, Kathmandu, Nepal

Assistant Professor, Department of Paediatrics, Patan Hospital

Rateena Rajbhandari, Patan Academy of Health Sciences, Lalitpur, Kathmandu, Nepal

Assistant Professor, Department of Paediatrics, Patan Hospital

Anu Maharjan, Patan Academy of Health Sciences, Lalitpur, Kathmandu, Nepal

Lecturer, Department of Surgery, Patan Hospital

Anil Raj Ojha, Patan Academy of Health Sciences, Lalitpur, Kathmandu, Nepal

Associate Professor, Department of Paediatrics, Patan Hospital

Ganesh Shah, Patan Academy of Health Sciences, Lalitpur, Kathmandu, Nepal

Professor, Department of Paediatrics, Patan Hospital

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Published

2021-12-31

How to Cite

Tuladhar, S., Amatya, P., Rajbhandari, R., Maharjan, A., Ojha, A. R., & Shah, G. (2021). Clinical profile and outcome of COVID-19 in pediatric hematology-oncology patients. Journal of Patan Academy of Health Sciences, 8(3), 14–22. https://doi.org/10.3126/jpahs.v8i3.30423

Issue

Section

COVID-19: Original Articles