Effectiveness of Pyridostigmine and Pyridoxine in Vinca AlkaloidInduced Cranial Neuropathy – A Case Series

Authors

  • Aparajita Gupta Department of Paediatrics, Command Hospital (EC), 17/1E, Alipore Rd, Alipore Police Line, Alipore, Kolkata, West Bengal 700027, India
  • Shuvendu Roy Department of Paediatrics, Command Hospital (EC), 17/1E, Alipore Rd, Alipore Police Line, Alipore, Kolkata, West Bengal 700027, India https://orcid.org/0000-0003-4095-8953
  • Prateep Paul Department of Paediatrics, Command Hospital (EC), 17/1E, Alipore Rd, Alipore Police Line, Alipore, Kolkata, West Bengal 700027, India

DOI:

https://doi.org/10.3126/jnps.v42i2.42865

Keywords:

Neurotoxicity, Oncological urgency, Reversible Neuropathy

Abstract

The neurotoxicity of the vinca alkaloids in the form of peripheral neuropathy is well known, however, cranial neuropathy is not widely recognized especially in children. We describe here in three children with malignancies who developed vinca alkaloid induced cranial nerve palsies during treatment which resolved on institution of pyridoxine and pyridostigmine. Vinca-alkaloid-induced cranial nerve palsies represent a potentially dangerous but reversible condition.

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Published

2022-12-31

How to Cite

Gupta, A., Roy, S. ., & Paul, P. (2022). Effectiveness of Pyridostigmine and Pyridoxine in Vinca AlkaloidInduced Cranial Neuropathy – A Case Series. Journal of Nepal Paediatric Society, 42(2), 77–79. https://doi.org/10.3126/jnps.v42i2.42865

Issue

Vol. 42 No. 2 (2022)

Section

Case Series

License

Copyright (c) 2022 Aparajita Gupta, Shuvendu Roy, Prateep Paul

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