Efficacy of Hyoscine Butylbromide Versus Drotaverine in Relieving Acute Nonspecific Abdominal Pain in Children- A Non - Randomized Trial

Authors

  • Pradip Kumar Paudel 1Department of Paediatrics, Province Hospital, Surkhet, Nepal
  • Sudha Basnet Department of Paediatrics, Maharajgunj Medical Campus, Institute of Medicine, TUTH, Maharajgunj, Kathmandu, Nepal
  • Merina Shreshtha Department of Paediatrics, Maharajgunj Medical Campus, Institute of Medicine, TUTH, Maharajgunj, Kathmandu, Nepal

DOI:

https://doi.org/10.3126/jnps.v42i1.39773

Keywords:

Children, drotaverine, face pain score-revised, hyoscine, nonspecific abdominal pain

Abstract

Introduction: Acute abdominal pain is a very common complaint for children presenting to the emergency department (ED). The purpose of this study was to compare efficacy of hyoscine and drotaverine for relieving acute nonspecific abdominal pain in children presenting to ED.

Methods: Total of 52 children aged six years to 16 years were enrolled in a non-randomized trial at Paediatric ED of TUTH from Dec 2017 to June 2018, and randomly allocated to drotaverine or hyoscine groups; 26 in each group. Face pain score-revised tool was used to measure the efficacy of the drug. The primary outcome was to measure the reduction of face pain score (Self-reported) by at least 2 / 10 at 60 minutes after ingestion of study intervention. Other outcomes were requirement of rescue analgesia and adverse effects of drugs.

Results: A total of 20 (77%) in hyoscine and 21 (81%) in drotaverine group responded to oral medication at the end of 60 minutes of oral administration and the difference was not statistically significant (p=0.808). Vomiting was only adverse event present in five (19%) in drotaverine and two (8%) in hyoscine groups, respectively.

Conclusions: In this single center randomized controlled trial, both hyoscine and drotaverine were found to be equally efficacious for relieving acute non-specific abdominal pain in children.

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Published

2022-11-27

How to Cite

Kumar Paudel, P. ., Basnet, S. ., & Shreshtha, M. (2022). Efficacy of Hyoscine Butylbromide Versus Drotaverine in Relieving Acute Nonspecific Abdominal Pain in Children- A Non - Randomized Trial. Journal of Nepal Paediatric Society, 42(1), 45–50. https://doi.org/10.3126/jnps.v42i1.39773

Issue

Vol. 42 No. 1 (2022)

Section

Original Articles

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Copyright (c) 2022 Pradip Kumar Paudel Pradip Kumar Paudel

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