Red Cell Distribution Width Value Supports the Diagnosis of Neonatal Sepsis in 34-42 Week Gestational Age Neonates
DOI:
https://doi.org/10.3126/jnps.v41i2.33189Keywords:
Diagnosis, Neonatal sepsis, Neonates, Red Cell Distribution Width, RDWAbstract
Introduction: Neonatal sepsis is an emergency because delayed treatment can be fatal, whereas the diagnosis is challenging because of the unspecific clinical manifestation. Bacterial culture is the gold standard for the diagnosis, but it takes several days to get the results, which often come out as negative. This study aims to determine the diagnostic value of RDW to support the diagnosis of neonatal sepsis in 34 – 42 week gestational age neonates.
Methods: This cross-sectional diagnostic study used secondary data obtained from Medical Record Installation and Clinical Pathology Laboratory of Dr. Mohammad Hoesin General Central Hospital in Palembang, Indonesia. One hundred and thirty-four medical records were statistically analysed using Med Calc Version 19 to determine the cut-off point and diagnostic value of RDW in the diagnosis of neonatal sepsis.
Results: One hundred and thirty-four subjects consisting 32 septic neonates (23.9%) and 102 non-septic neonates (76.1%) were reviewed. Most of them were males (80/134) and preterm (73/134) with normal birth weight (99/134). At the cut-off point of > 16.2%, RDW value was significantly able to predict neonatal sepsis (p = 0.000, p < α) with prediction power (AUC) of 0.780 (fair). The diagnostic values were sensitivity 84.37%, specificity 57.84%, positive predictive value 38.57%, negative predictive value 92.19%, positive likelihood ratio 2.00 and negative likelihood ratio 0.27.
Conclusions: Red cell distribution width value might potentially be used as a diagnostic marker to support the diagnosis of neonatal sepsis in 34 – 42 week gestational age neonates. However, further study is needed to support this statement.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Bella Stevanny, Atika Akbari, Mariana
![Creative Commons License](http://i.creativecommons.org/l/by/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).