Impact of Anaemia on the Severity of Acute Bronchiolitis in Infants

Authors

  • Elif Çelik Department of Paediatrics, General Paediatrics Unit, Adnan Menderes University, Faculty of Medicine, Aydin, Turkey
  • Serkan Fazlı Çelik Department of Paediatric Cardiology Unit, Adnan Menderes University, Faculty of Medicine, Aydin, Turkey
  • Şükrü Güngör Department of Paediatric Gastroenterology Unit, Adnan Menderes University, Faculty of Medicine, Aydin, Turkey
  • Adem Dursun Paediatric Intensive Care, Kayseri City Hospital, Kayseri, Turkey

DOI:

https://doi.org/10.3126/jnps.v41i1.30704

Keywords:

Acute bronchiolitis severity, haemoglobin level, infant

Abstract

Introduction: Although anaemia is a predisposing factor in the occurrence of lower respiratory tract infections, there is limited data about the relationship between anaemia and acute bronchiolitis in infants. The aim of this study is to determine whether anaemia is an independent clinical condition increasing the severity of acute bronchiolitis in infants.

Methods: This retrospective study was conducted on 163 infants (101 acute bronchiolitis and age and sex matched 62 controls), aged between one month to two years. According to the clinical severity of the disease, patients were divided as having mild, moderate and severe acute bronchiolitis. Haemoglobin (Hb) level was considered low when below 11 gm/dL, which is less than 2 standard deviation (SD).

Results: Median Hb and mean cell haemoglobin concentration (MCHC) levels were significantly lower in acute bronchiolitis patients than controls {10.1 gm/dL (9.6 - 10.6 gm/dL) vs. 11.2 gm/dL (10.6 - 12.1 gm/dL); p < 0.001)}, and {33.6 (32.5 - 34.1 gm/dL) vs. 34 gm/dL (33.1 - 34.5 gm/dL) p = 0.012}. Conversely, median red cell distribution width (RDW) was higher {14.4% (13.5 - 15.6%) vs. 14.1% (13.1-15%)}. When evaluated by logistic regression analysis, the risk of severe bronchiolitis increased 10 times in acute bronchiolitis patients with a Hb value ≤ 10 gm/dL. Also, there was a significant negative correlation between Hb level and bronchiolitis severity (r :- 0.423, p < 0.001). Furthermore, the patients who had Hb value under 9.95 gm/dL had risk of more severe bronchiolitis with 73.7% sensitivity and 83.3% specificity than other patients.

Conclusions: Anaemic infants are more susceptible to acute bronchiolits and as the degree of anaemia increases, they are more severely affected.

Downloads

Download data is not yet available.
Abstract
408
PDF
362
Cover JNPS

Downloads

Published

2021-04-24

How to Cite

Çelik E., Çelik, S. F., Güngör, Şükrü, & Dursun, A. (2021). Impact of Anaemia on the Severity of Acute Bronchiolitis in Infants. Journal of Nepal Paediatric Society, 41(1), 73–79. https://doi.org/10.3126/jnps.v41i1.30704

Issue

Vol. 41 No. 1 (2021)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).