Evaluation of Ischaemia Modified Albumin as a Marker of Oxidative Stress in Beta Thalassemia Major Children

  • K Jagadish Kumar Department of Paediatrics, JSS Medical College, JSS Academy Of Higher Education And Research., Mysore, India
  • Smriti Bhagiratha Department of Paediatrics, JSS Medical College, JSS Academy Of Higher Education And Research., Mysore, India
  • Prashanth Vishwanath Department of Biochemistry, JSS Medical College, JSS Academy Of Higher Education And Research, Mysore, India
Keywords: β-thalassemia major, Ferritin, Ischemia modified albumin (IMA), Oxidative stress

Abstract

Introduction: Iron overload in thalassemia catalyses the production of a variety of reactive oxygen species leading to cumulative cell damage. Ischemia modified albumin (IMA) is an end product of oxidative stress. It is imperative to pick up oxidative stress early in order to prevent the organ damage in thalassemia. Therefore this study was undertaken to estimate IMA levels and to see the correlation between ferritin and IMA to establish whether ferritin can be a proxy marker for oxidative stress.

Methods: A total of 76 children were included in the study out of which 46 were diagnosed cases of β- Thalassemia major and 30 formed the healthy controls. Pre transfusion haemoglobin, AST, ALT, ferritin and IMA levels were estimated and compared with healthy control children. Correlation was drawn between haemoglobin, AST, ALT, ferritin with IMA.

Results: There is significant elevation in the level of IMA and ferritin in children with Thalassemia major as compared to the healthy controls (p = < 0.001). There was a significant positive correlation between ferritin and IMA and a significant negative correlation between haemoglobin % and IMA. Regression relationship between ferritin and IMA established that IMA (ng/ mL) = 246.118 + 0.829 (Ferritin ng/dL).

Conclusions: IMA levels were significantly elevated in β- thalassemia major children and correlated positively with ferritin levels. By establishing a regression relationship between ferritin and IMA levels, we can fairly estimate the levels of IMA. Hence, we can utilise ferritin as a proxy marker of oxidative stress instead of IMA.

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Abstract
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Published
2021-04-24
How to Cite
Kumar, K., Bhagiratha, S., & Vishwanath, P. (2021). Evaluation of Ischaemia Modified Albumin as a Marker of Oxidative Stress in Beta Thalassemia Major Children. Journal of Nepal Paediatric Society, 41(1), 61-66. https://doi.org/10.3126/jnps.v41i1.29931
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Original Articles