Etiological Trends and Epidemiological Profile of Tropical Fever in Children Presenting with Acute Undifferentiated Fever at a Tertiary Care Centre in North India

  • Monika Matlani Department of Microbiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
  • Pramod Kumar Department of Paediatrics, Vardhman Mahavir Medical College and Safdarjung hospital new Delhi, India http://orcid.org/0000-0001-5147-1820
  • Shyam S Meena Department of Paediatrics, Vardhman Mahavir Medical College and Safdarjung hospital new Delhi, India
  • Mohan Vashistha Department of Paediatrics, Vardhman Mahavir Medical College and Safdarjung hospital new Delhi, India
  • Vinita Dogra Department of Paediatrics, Vardhman Mahavir Medical College and Safdarjung hospital new Delhi, India
Keywords: Acute undifferentiated fever (AUF), Dengue, Malaria, Scrub Typhus, Tropical Fevers

Abstract

Introduction: The objective of this study was to determine the etiology of acute undifferentiated fevers (AUF) in hospitalised children with in a tertiary care centre in North India. The various causes of acute undifferentiated fevers included dengue, malaria, scrub typhus, enteric fever, leptospirosis and Chikungunya. The clinical spectrum and therapeutic outcome of these cases was also studied.

Methods: This retrospective study was conducted over a period of 6 months from June 2019 to December 2019. The clinical information of 126 children who tested positive for any of the causes of AUF namely dengue, malaria, scrub typhus, enteric fever, chikungunya and leptospirosis was obtained from the Paediatrics Department. The information was recorded in a predesigned proforma. Various tests performed for the diagnosis of these illnesses were noted. They included dengue NS1 antigen ELISA and IgM ELISA, peripheral blood smear (PBS) for malarial parasite and rapid malarial antigen detection test (RMAT), scrub typhus IgM ELISA, leptospira IgM ELISA, and Chikungunya IgM ELISA.

Results: The diagnosis of AUF were dengue (55.5%; 70/126), malaria (19%; 24/126) and scrub typhus (19%; 24/126), enteric fever (4.7%;6/126) and Chikungunya (1.5%; 2/126). The most common presenting symptom was fever or pyrexia followed by myalgia, generalised aches and pains in the body and vomiting. Commonly observed complications included thrombocytopenia, hepatitis and shock.

Conclusions: Dengue, malaria and scrub typhus are the major causes of AUF in the hospitalised children with dengue being the most prevalent infection. The study further emphasises the need to develop a systematic approach to the diagnosis of AUFs. This should be using a combination of clinical, epidemiological and laboratory parameters, which will be very useful for developing a relevant action plan for treatment and prevention of such fevers in any hospital setup.

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Author Biography

Pramod Kumar, Department of Paediatrics, Vardhman Mahavir Medical College and Safdarjung hospital new Delhi, India

Assistant Professor ,Neonatology Division, Department of Paediatrics,  Vardhman Mahavir Medical College & Safdarjung hospital, New Delhi, India

Published
2021-04-24
How to Cite
Matlani, M., Kumar, P., Meena, S., Vashistha, M., & Dogra, V. (2021). Etiological Trends and Epidemiological Profile of Tropical Fever in Children Presenting with Acute Undifferentiated Fever at a Tertiary Care Centre in North India. Journal of Nepal Paediatric Society, 41(1), 54-60. https://doi.org/10.3126/jnps.v41i1.29595
Section
Original Articles