Validity of Bilirubin Measured by Biliscan (Smartphone Application) in Neonatal Jaundice – An Observational study

  • Swapna Lingaldinna Department of Neonatology, Niloufer Hospital, Osmania Medical College, Hyderabad, India
  • Kalyan Chakravarthy Konda Department of Neonatology, Niloufer Hospital, Osmania Medical College, Hyderabad, India
  • Narahari Bapanpally Department of Paediatrics, Niloufer Hospital, Osmania Medical College, Hyderabad, India
  • Madireddy Alimelu Department of Neonatology, Niloufer Hospital, Osmania Medical College, Hyderabad, India
  • Himabindu Singh Department of Neonatology, Niloufer Hospital, Osmania Medical College, Hyderabad, India
  • Meghna Ramaraju Department of Paediatrics, Niloufer Hospital, Osmania Medical College, Hyderabad, India
Keywords: Bilirubin, Bhutani's normogram, Biliscan, phototherapy, Smartphone, Transcutaneous bilirubinometer

Abstract

Introduction: Bilirubin is a frequently ordered investigation in neonatal intensive care units and out-patient practice during follow- up. The gold standard for its estimation is serum bilirubin which is invasive resulting in parenteral apprehension, pain, discomfort and iatrogenic anaemia in a neonate, while the non-invasive measurement by transcutaneous bilirubinometer is not available in all the centres because of its cost. Biliscan is a smartphone application that uses a phone’s inbuilt camera and a colour calibration card to detect neonatal jaundice. We compared bilirubin measured by Biliscan with reference to serum bilirubin among neonates admitted to a tertiary care centre.

Methods: We conducted an observational study from June-2019 to September-2019 at a tertiary care centre in Hyderabad, India. Inborn neonates (greater than > 35 weeks gestational age at birth, and less than a week old) who required bilirubin estimation, underwent both invasive serum sampling and non-invasive estimation by Biliscan. Photograph of the baby’s chest was captured using the colour calibration card of the Biliscan application. Bilirubin values derived from the Biliscan application were compared to those derived from blood samples.

Results: A total of 143 neonates were enrolled. The mean bilirubin value estimated by serum sampling was 11.9 g/dl against 13.1 g/dl of that derived from smartphone application. Biliscan and serum bilirubin showed moderate agreement with a correlation coefficient of 0.6. Bland- Altman plot constructed showed bias of 1.1 with the limits of agreement ranging from -3 to +5.3. Biliscan had a good sensitivity of 90% in identifying high levels of serum bilirubin (> 95th percentile on Bhutani nomogram).

Conclusion: Biliscan application is a non-invasive, real-time, inexpensive and an easily available method that cannot replace serum bilirubin, however can complement and has the potential to help in screening neonates thus facilitating recognition of jaundice early and minimising the number of invasive pricks.

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Abstract
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Published
2021-04-24
How to Cite
Lingaldinna, S., Konda, K., Bapanpally, N., Alimelu, M., Singh, H., & Ramaraju, M. (2021). Validity of Bilirubin Measured by Biliscan (Smartphone Application) in Neonatal Jaundice – An Observational study. Journal of Nepal Paediatric Society, 41(1), 93-98. https://doi.org/10.3126/jnps.v40i3.29412
Section
Original Articles