Comparison of Intranasal Midazolam and Rectal Diazepam as Anticonvulsant in Children

Authors

  • Prastiya Indra Gunawan Pediatric Neurology Airlangga University Surabaya
  • Fadil Rulian Paediatric Neurology, Airlangga University Surabaya
  • Darto Saharso Paediatric Neurology, Airlangga University Surabaya

DOI:

https://doi.org/10.3126/jnps.v35i2.13581

Keywords:

Seizures, Intranasal midazolam, Rectal diazepam, Children, Effective

Abstract

Introduction: Rectal diazepam is reputed as the gold-standard management of childhood seizures. Otherwise, intranasal (IN) midazolam has no first-pass metabolism and faster onset of action. The effectiveness and easier route of these drugs are important choices for faster seizure cessation. The aim of this study was to clarify the effectiveness of intranasal midazolam compared with rectal diazepam for seizure termination.

Material and Methods: The children, one month until 18 years of age, presented with acute seizures. Patients were randomly classified into two groups with either received intranasal midazolam or rectal diazepam for seizure termination. Interval time of drug administration to cease seizure was compared. The log-rank analysis was used for statistical analysis. Side effect of both drugs were evaluated.

Results: There were 60 patients enrolled the study, 30 in each group. The median time interval for seizures cessation with intranasal midazolam was 42 seconds, otherwise in rectal diazepam group was 180 seconds. There was statistically significant difference interval time between two groups (p<0.01). None of the both groups had any significant side effects statistically.

Conclusion: Intranasal midazolam is effective to terminate a seizure in children. It can be used as an alternative treatment for seizures in patients with intravenous or rectal route difficulties.

J Nepal Paediatr Soc 2015;35(2):117-122  

Downloads

Download data is not yet available.
Abstract
1595
PDF
1130

Downloads

Published

2016-01-20

How to Cite

Gunawan, P. I., Rulian, F., & Saharso, D. (2016). Comparison of Intranasal Midazolam and Rectal Diazepam as Anticonvulsant in Children. Journal of Nepal Paediatric Society, 35(2), 117–122. https://doi.org/10.3126/jnps.v35i2.13581

Issue

Vol. 35 No. 2 (2015)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).