Neuroprotective effect of Scutellaria baicalensis flavones against global ischemic model in rats

Authors

  • Bjakta Prasad Gaire Department of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University, Seoul
  • Young Ock Kim Department of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University, Seoul
  • Zhen Hua Jin Department of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University, Seoul
  • Juyeon Park Korea Institute of Science and Technology for Eastern Medicine (KISTEM), NeuMed Co., Inc., Seoul
  • Hoyoung Choi Department of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University, Seoul
  • Youngmin Bu Department of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University, Seoul
  • Hocheol Kim Department of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University, Seoul

DOI:

https://doi.org/10.3126/jnpa.v27i1.12144

Keywords:

Scutellaria baicalensis, neuroprotection, ischemia, wogonin, baicalein

Abstract

Scutellaria baicalensis Georgi (SB) is the medicinal plants mainly used in traditional Chinese medicine. It has been used for the treatment of various chronic inflammatory syndromes including respiratory disease, fever and gastric ulcer in traditional Eastern medicine and its major components; baicalin, baicalein and wogonin; were reported to have various biological effects. The aim of this study was to isolate the neuroprotective flavones from the root of S. baicalensis (SB) by bioactivity-guided fractionation of S. baicalensis methanol extract (SBME). Neuroprotective effect of isolated flavones, namely was studied on global ischemic model in rat by 4-VO. SBME was fractionated with different solvent and resulting fractions were administered at a dose of 25 mg/kg to the rat and potent neuroprotective fractions were sub-fractionated. At a dose of 10 mg/kg, isolated compounds, wogonin, and baicalein inhibited the hippocampal neuronal cell death by 78.6% and 81.0% respectively. Our study suggested that SB and its isolated flavones have potential neuroprotective effect and these findings may be one of the alternative therapies for the management of stroke and other neurodegenerative diseases.

DOI: http://dx.doi.org/10.3126/jnpa.v27i1.12144

Journal of Nepal Pharmaceutical Association 2014 Vol.XXVII: 1-8

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Published

2015-02-19

How to Cite

Gaire, B. P., Kim, Y. O., Jin, Z. H., Park, J., Choi, H., Bu, Y., & Kim, H. (2015). Neuroprotective effect of Scutellaria baicalensis flavones against global ischemic model in rats. Journal of Nepal Pharmaceutical Association, 27(1), 1–8. https://doi.org/10.3126/jnpa.v27i1.12144

Issue

Vol. 27 No. 1 (2014)

Section

Articles