Antibiotic Susceptibility Pattern of Gram-negative Isolates of Lower Respiratory Tract Infection

Authors

  • Rakshya Nepal Central Department of Microbiology, Tribhuvan University, Kritipur, Kathmandu
  • Basudha Shrestha Department of Microbiology
  • Deepak Man Joshi Department of Medicine, phect-NEPAL/ Kathmandu Model Hospital
  • Rajesh Dhoj Joshi Department of Medicine, phect-NEPAL/ Kathmandu Model Hospital
  • Sanjit Shrestha Department of Microbiology
  • Anjana Singh Central Department of Microbiology, Tribhuvan University, Kritipur, Kathmandu

Keywords:

Extended -spectrum β-lactamase, multidrug-resistance

Abstract

Background:  Lower respiratory tract infection is a common cause of morbidity and mortality worldwide. A crosssectional study was carried out with an objective to study the antibiogram of Gram-negative isolates of patients with lower respiratory tract infection visiting Kathmandu Model Hospital.

Methods: A total of 274 specimens including sputum, endotracheal aspirates, suction tips were cultured as per standard microbiological technique. Antibiotic susceptibility and detection of Extended-spectrum beta- lactamases (ESBLs) were performed following Clinical Laboratory Standard Institute (CLSI 2014) guidelines.

Results: Respiratory pathogens were recovered from 24.6% (n=65) cases. Klebsiella pneumoniae (40%) was the commonest isolates. The highest prevalence of multidrug-resistance (69.23%) was observed in Acinetobacter calcoaceticus baumannii complex. Extended-spectrum beta- lactamases were detected in Escherichia coli (n=4), Klebsiella pneumoniae (n=4) and Acinetobacter calcoaceticus baumannii complex (n=1).

Conclusions: High prevalence of multidrug-resistance and extended- spectrum beta- lactamase producers were observed in respiratory isolates. For effective management of lower respiratory tract infections, an ultimate and detailed microbiological diagnosis and susceptibility testing is required.

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Published

2018-03-18

How to Cite

Nepal, R., Shrestha, B., Joshi, D. M., Joshi, R. D., Shrestha, S., & Singh, A. (2018). Antibiotic Susceptibility Pattern of Gram-negative Isolates of Lower Respiratory Tract Infection. Journal of Nepal Health Research Council, 16(1), 22–26. Retrieved from https://nepjol.info/index.php/JNHRC/article/view/19358

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Original Articles